The worldwide incidence of bone disorders and conditions has trended steeply upward and
is expected to double by 2020, especially in populations where aging is coupled with …

The controlled delivery of growth factors and cells within biomaterial carriers can enhance
and accelerate functional bone formation. The carrier system can be designed with pre …

Bone vasculature and bone marrow vascular niches supply oxygen, nutrients, and secrete
angiocrine factors required for the survival, maintenance, and self‐renewal of stem and …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

Significant advances have been made in bone tissue engineering (TE) in the past decade.
However, classical bone TE strategies have been hampered mainly due to the lack of …

Regenerating bone tissue involves complex, temporal and coordinated signal cascades of
which bone morphogenic protein-2 (BMP-2) and vascular endothelial growth factor …

Natural bone growth greatly depends on the precedent vascular network that supplies
oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue …

Massive segmental bone defects (SBD) are mostly treated by removing the fibula and
transplanting it complete with blood supply. While revolutionary 50 years ago, this remains …

The enhancement of bone regeneration with biological agents including osteogenic growth
factors and mesenchymal stem cells (MSCs) is becoming a clinical reality. Many exciting …

Bone regeneration seems to be dependant on cell communication between osteogenic and
endothelial cells arising from surrounding blood vessels. This study aims to determine …