Cardiovascular disease (CVD) is the primary cause of mortality worldwide. Cardiac
autonomic dysfunction seems to be related to the genesis of several CVD s and is also …

The exercise pressor reflex (a peripheral neural reflex originating in skeletal muscle)
contributes significantly to the regulation of the cardiovascular system during exercise …

Peripheral arterial disease (PAD) is a common vascular disease that reduces blood flow
capacity to the legs of patients. PAD leads to exercise intolerance that can progress in …

Background—The muscle hypothesis implicates abnormalities in peripheral muscle as a
source for the stimulus to the symptoms and reflex abnormalities seen in chronic heart …

It is suggested that mechanoreceptors in muscle play an important role in the exercise
pressor reflex. However, it has not been verified whether isolated stimulation of the …

Aims Following a large myocardial infarction (MI), remaining viable muscle often undergoes
pathological remodelling and progresses towards chronic heart failure. Mitochondria may …

Neurohumoral activation has been recognized as one of the hallmarks in the compensatory
response during the development of chronic heart failure (CHF), whatever its origin. 1–4 A …

Previous studies have demonstrated that muscle mechanoreflex and metaboreflex controls
are altered in heart failure (HF), which seems to be due to changes in cyclooxygenase …

The muscle metaboreflex is enhanced in chronic heart failure (CHF) patients, and this fact
has been associated with the early fatigue shown by these patients in response to exercise …

Background—In heart failure, exercise elicits excessive increases in mean arterial pressure
(MAP) and heart rate (HR). Using a novel rat model, we previously demonstrated that this …