As a compartment border, the nuclear envelope (NE) needs to serve as both a protective
membrane shell for the genome and a versatile communication interface between the …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Oral mucosal wound healing has long been regarded as an ideal system of wound
resolution. However, the intrinsic characteristics that mediate optimal healing at mucosal …

Diabetes impacts approximately 200 million people worldwide, of whom approximately 10%
are affected by type 1 diabetes (T1D). The application of genome-wide association studies …

Mutations in genes encoding the intermediate filament nuclear lamins and associated
proteins cause a wide spectrum of diseases sometimes called “laminopathies.” Diseases …

Cells respond to mechanical forces by activating specific genes and signaling pathways that
allow the cells to adapt to their physical environment. Examples include muscle growth in …

Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in
dilated cardiomyopathy (DCM), a major cause of chronic heart failure, presumably through …

A-and B-type lamins are the major intermediate filaments of the nucleus. Lamins engage in
a plethora of stable and transient interactions, near the inner nuclear membrane and …

A-type lamins (lamins A and C), encoded by the LMNA gene, are major protein constituents
of the mammalian nuclear lamina, a complex structure that acts as a scaffold for protein …

One hypothesis to explain how mutations in the same nuclear envelope proteins yield
pathologies focused in distinct tissues is that as yet unidentified tissue-specific partners …