Highlights•Compositions of IDPs fall into distinct classes.•Compositional classes encode
preferences for distinct conformational classes.•Functions of disordered proteins are …

Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded
compartments and, within these, some are further organized into non-membrane-bounded …

Phase transitions of linear multivalent proteins control the reversible formation of many
intracellular membraneless bodies. Specific non-covalent crosslinks involving …

Flexible polypeptide linkers composed of glycine and serine are important components of
engineered multidomain proteins. We have previously shown that the conformational …

The organization of membranes, the cytosol, and the nucleus of eukaryotic cells can be
controlled through phase separation of lipids, proteins, and nucleic acids. Collective …

Peptide motifs embedded within intrinsically disordered regions (IDRs) of proteins are often
the sites of posttranslational modifications that control cell-signaling pathways. How do IDR …

Machine learning has achieved remarkable success across a broad range of scientific and
engineering disciplines, particularly its use for predicting native protein structures from …

Intrinsically disordered proteins (IDPs) play crucial roles in cellular regulatory networks and
are now recognized to often remain highly dynamic even in specific interactions and …

Intrinsically disordered proteins and regions (IDPs/IDRs) are characterized by well-defined
sequence-to-conformation relationships (SCRs). These relationships refer to the sequence …

Intrinsically disordered proteins (IDPs) are over-represented in major disease pathways and
have attracted significant interest in understanding if and how they may be targeted using …