[PDF][PDF] HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens
Humanity is currently facing the challenge of two devastating pandemics caused by two very
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …
different RNA viruses: HIV-1, which has been with us for decades, and SARS-CoV-2, which …
Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
[HTML][HTML] Properties of MHC class I presented peptides that enhance immunogenicity
JJA Calis, M Maybeno, JA Greenbaum… - PLoS computational …, 2013 - journals.plos.org
T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …
their effector functions. Several studies demonstrate that some peptides are more …
Population genomics of rapid adaptation by soft selective sweeps
Organisms can often adapt surprisingly quickly to evolutionary challenges, such as the
application of pesticides or antibiotics, suggesting an abundant supply of adaptive genetic …
application of pesticides or antibiotics, suggesting an abundant supply of adaptive genetic …
[HTML][HTML] Acute HIV-1 infection
Acute HIV-1 Infection | NEJM Skip to main content NEJM Group Follow Us Facebook Twitter
Instagram YouTube LinkedIn Prepare to become a physician, build your knowledge, lead a …
Instagram YouTube LinkedIn Prepare to become a physician, build your knowledge, lead a …
Accurate sampling and deep sequencing of the HIV-1 protease gene using a Primer ID
CB Jabara, CD Jones, J Roach… - Proceedings of the …, 2011 - National Acad Sciences
Viruses can create complex genetic populations within a host, and deep sequencing
technologies allow extensive sampling of these populations. Limitations of these …
technologies allow extensive sampling of these populations. Limitations of these …
[HTML][HTML] Modeling the within-host dynamics of HIV infection
AS Perelson, RM Ribeiro - BMC biology, 2013 - Springer
The new field of viral dynamics, based on within-host modeling of viral infections, began with
models of human immunodeficiency virus (HIV), but now includes many viral infections …
models of human immunodeficiency virus (HIV), but now includes many viral infections …
Bottlenecks in HIV-1 transmission: insights from the study of founder viruses
SB Joseph, R Swanstrom, ADM Kashuba… - Nature Reviews …, 2015 - nature.com
HIV-1 infection typically results from the transmission of a single viral variant, the
transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information …
transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information …
Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived …
C Ochsenbauer, TG Edmonds, H Ding… - Journal of …, 2012 - Am Soc Microbiol
Genome sequences of transmitted/founder (T/F) HIV-1 have been inferred by analyzing
single genome amplicons of acute infection plasma viral RNA in the context of a …
single genome amplicons of acute infection plasma viral RNA in the context of a …