Background Recent studies suggest that tirzepatide, a dual glucose-dependent
insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has …

Background Aortic valve stenosis is a progressive disorder with variable progression rates.
The factors affecting aortic stenosis (AS) progression remain largely unknown. Objectives …

Importance Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to
surgical aortic valve replacement and is the treatment of choice for patients at high operative …

Background There is a growing number of trials examining the effectiveness of
pharmacotherapies for obesity, however, little is known about placebo and nocebo effect in …

Objectives Patients undergoing surgery for severe aortic stenosis (SAS) can be treated with
either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement …

Abstract Background Randomized controlled trials (RCTs) of lipid-lowering therapy (LLT) in
which the control groups received placebo without background LLT offer unique insights into …

Introduction In transcatheter aortic valve implantation (TAVI), assessment of aortic valve
calcification is not as standardized as aortic annulus measurement. Aortic valve calcification …

OBJECTIVES Limited data are available from randomized trials comparing outcomes
between transcatheter aortic valve replacement (TAVR) and surgery in patients with different …

Background: TAVR is a safe alternative to surgical aortic valve replacement (SAVR);
however, sex-related differences are still debated. This research aimed to examine gender …

Background During the past decade, the use of transcatheter aortic valve replacement
(TAVR) was extended beyond treatment‐naïve patients and implemented for treatment of …