The pineal gland is a unique organ that synthesizes melatonin as the signaling molecule of
natural photoperiodic environment and as a potent neuronal protective antioxidant. An intact …

Melatonin is a signal molecule that modulates the biological circadian rhythms of
vertebrates. Melatonin deficiency is thought to be associated with several disorders …

Melatonin is the primary circadian output signal from the brain and is mainly synthesized in
pinealocytes. The rhythm and secretion of melatonin are under the control of an …

Sleep is an essential biological phenomenon, being a physiological and behavioral process
necessary for quality of life. Melatonin is a circadian hormone produced at night by the …

Exposure to the space environment induces a number of pathophysiological outcomes in
astronauts, including bone demineralization, sleep disorders, circadian clock dysregulation …

Previous studies have revealed that melatonin could play a role in anti-osteoporosis and
promoting osteogenesis. However, the effects of melatonin treatment on osteoporotic bone …

Cancer-related bone erosion occurs frequently in bone metastasis and is associated with
severe complications such as chronic bone pain, fractures, and lower survival rates. In …

Melatonin is an important endogenous hormone that modulates homeostasis in the
microenvironment. Recent studies have indicated that serum melatonin levels are closely …

The zebrafish has become an excellent model for the study of human diseases because it
offers many advantages over other vertebrate animal models. The pineal gland, as well as …

Background and Purpose Melatonin is a neurohormone involved in bone homeostasis.
Melatonin directs bone remodelling and the role of bone marrow mesenchymal stem cells …