The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …

Abstract The Human antigen R (HuR) protein is an RNA-binding protein, ubiquitously
expressed in human tissues, that orchestrates target RNA maturation and processing both in …

Commonly observed in colorectal cancer is the elevated expression of the prostaglandin
(PG) synthase COX-2. In normal intestinal epithelium, the COX-2 mRNA is targeted for rapid …

The microRNA (miRNA)-mediated repression of protein synthesis in mammalian cells is a
reversible process. Target mRNAs with regulatory AU-rich elements (AREs) in their 3 …

Human antigen R (HuR) is a key regulator of cellular mRNAs containing adenylate/uridylate–
rich elements (AU-rich elements; AREs). These are a major class of cis elements within 3 …

Human RNA-binding protein (HuR), a ubiquitously expressed member of the Hu protein
family, plays an important role in mRNA degradation and has been implicated as a key post …

Gene expression in eukaryotes is subject to extensive regulation at posttranscriptional
levels. One of the most important sites of control involves mRNA 3′ untranslated regions …

Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which
bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Whereas the N-terminal …

RNA-binding proteins (RBPs) are involved in regulating all aspects of RNA metabolism,
including processing, transport, translation, and degradation. Dysregulation of RNA …

AU‐rich elements (ARE) exist in the 3′‐untranslated regions of the mRNA transcribed from
cell growth‐related genes such as proto‐oncogenes, cyclin‐related genes, and growth …