Lysosomal storage diseases (LSDs) are a group of over 70 diseases that are characterized
by lysosomal dysfunction, most of which are inherited as autosomal recessive traits. These …

Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as
being involved in formating the genetic and energy materials, supporting the structure of …

Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

Preclinical strategies that are used to identify potential drug candidates include target-based
screening, phenotypic screening, modification of natural substances and biologic-based …

Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …

Glycobiology: Toward Understanding the Function of Sugars | Chemical Reviews ACS ACS
Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

Niemann–Pick disease type C (NP-C) is a rare inherited neurovisceral disease caused by
mutations in either the NPC1 (in 95% of cases) or the NPC2 gene (in around 5% of cases) …

Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

Abstract Objective Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive,
neurodegenerative disease associated with a wide variety of progressive neurological …

Alkaloids mimicking the structures of monosaccharides are now believed to be widespread
in plants and microorganisms, and these sugar mimics inhibit glycosidases because of a …