Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are
associated with multiple kidney abnormalities. Young patients with SCD have elevated …

Sickle cell disease is a common and life-threatening haematological disorder that affects
millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in …

Background In patients with diabetes mellitus, hyperfiltration precedes the development of
albuminuria. Pediatric sickle cell anemia (SCA) patients have a high prevalence of …

Sickle cell disease is now a chronic adult illness characterized by progressive multiorgan
failure, particularly involving the brain and kidney. The etiology is multifactorial; it includes …

Abstract α‐Thalassemia is one of the most important genetic modulators of sickle cell
disease (SCD). Both beneficial and detrimental effects have been described previously. We …

Introduction: Renal dysfunction is among the most common complication of sickle cell
disease (SCD), from hyposthenuria in children to progression to overt chronic kidney …

Subjects with sickle cell trait (SCT) carry one copy of mutated β-globin gene at position E6V
at the origin of the production of sickle hemoglobin (HbS). Indeed, individuals with SCT have …

Sickle cell nephropathy is a major complication of sickle cell disease. It manifests in different
forms, including glomerulopathy, proteinuria, hematuria, and tubular defects, and frequently …

Sickle cell nephropathy results in chronic kidney disease (CKD), which is associated with
significant morbidity and mortality in sickle cell anemia (SCA). Albuminuria is an early …

Sickle cell disease (SCD) is a severe autosomal recessively inherited disorder of the red
blood cell characterized by erythrocyte deformation caused by the polymerization of the …