Blood transfusions are one of the most common procedures performed in hospitalized
patients. Yet, despite all of the measures taken to ensure the safety of the blood supply …

Despite the exhaustive search for an acceptable substitute to erythrocyte transfusion, neither
chemical-based products such as perfluorocarbons nor hemoglobin-based oxygen carriers …

In individuals with cystic fibrosis (CF), lung hyper-inflammation starts early in life and is
perpetuated by mucus obstruction and persistent bacterial infections. The continuous tissue …

Heme oxygenase (HO), the rate-limiting step in the degradation of heme to biliverdin, ferrous
ion, and carbon monoxide (CO), is an ancestral protective enzyme conserved across …

Overwhelming neutrophilic inflammation is a leading cause of lung damage in many
pulmonary diseases, including cystic fibrosis (CF). The heme oxygenase-1 (HO-1)/carbon …

Aneurysmal subarachnoid hemorrhage (aSAH) is a severe type of acute brain injury with
high mortality and burden of neurological sequelae. General management aims at early …

Objectives We discuss two main categories of blood substitutes: perfluorocarbons and
hemoglobin-based oxygen carriers. Methods We provide a review of the notable products …

Introduction: Aneurysmal subarachnoid hemorrhage (aSAH) represents 3% of all strokes in
the US. When the patient survives it can lead to permanent incapacity especially if the …

Carbon Monoxide (CO), at low concentrations, can have a variety of positive effects on the
body including anti-apoptosis, anti-inflammatory, anti-oxidative and anti-proliferative effects …

Vigilance is essential in the perioperative period. When blood is not an option for the patient,
especially in a procedure/surgery that normally holds a risk for blood transfusion, complexity …