Human embryonic kidney 293 cells: a vehicle for Biopharmaceutical Manufacturing, Structural Biology, and Electrophysiology: state of the art and future perspectives
J Hu, J Han, H Li, X Zhang, LL Liu, F Chen… - Cells Tissues …, 2018 - karger.com
Mammalian cells, eg, CHO, BHK, HEK293, HT-1080, and NS0 cells, represent important
manufacturing platforms in bioengineering. They are widely used for the production of …
manufacturing platforms in bioengineering. They are widely used for the production of …
Molecular basis of ancestral vertebrate electroreception
NW Bellono, DB Leitch, D Julius - Nature, 2017 - nature.com
Elasmobranch fishes, including sharks, rays, and skates, use specialized electrosensory
organs called ampullae of Lorenzini to detect extremely small changes in environmental …
organs called ampullae of Lorenzini to detect extremely small changes in environmental …
Surface collagen functionalization of electrospun poly (vinyl alcohol) scaffold for tissue engineering
A Pérez-Nava, AE Espino-Saldaña… - Process …, 2023 - Elsevier
The limited solubility of collagen is one of the main limitations to achieving electrospun mats
based on this biomacromolecule. Postelectrospinning functionalization has emerged as a …
based on this biomacromolecule. Postelectrospinning functionalization has emerged as a …
Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue
Four-domain voltage-gated Ca2+ (Cav) channels play fundamental roles in the nervous
system, but little is known about when or how their unique properties and cellular roles …
system, but little is known about when or how their unique properties and cellular roles …
NALCN ion channels have alternative selectivity filters resembling calcium channels or sodium channels
A Senatore, A Monteil, J van Minnen, AB Smit… - PLoS …, 2013 - journals.plos.org
NALCN is a member of the family of ion channels with four homologous, repeat domains that
include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene …
include voltage-gated calcium and sodium channels. NALCN is a highly conserved gene …
The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1. 2 and Cav1. 3 channels
V Taiakina, AN Boone, J Fux, A Senatore… - PloS one, 2013 - journals.plos.org
NSCaTE is a short linear motif of (x W xxx (I or L) xxxx), composed of residues with a high
helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type …
helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type …
Calmodulin regulates Cav3 T-type channels at their gating brake
Calcium (Ca v 1 and Ca v 2) and sodium channels possess homologous CaM-binding
motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a …
motifs, known as IQ motifs in their C termini, which associate with calmodulin (CaM), a …
Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro
AN Harracksingh, A Singh, TD Mayorova, B Bejoy… - Scientific Reports, 2024 - nature.com
PDZ domain mediated interactions with voltage-gated calcium (CaV) channel C-termini play
important roles in localizing membrane Ca2+ signaling. The first such interaction was …
important roles in localizing membrane Ca2+ signaling. The first such interaction was …
T-type channels become highly permeable to sodium ions using an alternative extracellular turret region (S5-P) Outside the selectivity filter*♦
A Senatore, W Guan, AN Boone, JD Spafford - Journal of Biological …, 2014 - ASBMB
T-type (Ca v 3) channels are categorized as calcium channels, but invertebrate ones can be
highly sodium-selective channels. We illustrate that the snail LCa v 3 T-type channel …
highly sodium-selective channels. We illustrate that the snail LCa v 3 T-type channel …
α-Actinin Promotes Surface Localization and Current Density of the Ca2+ Channel CaV1.2 by Binding to the IQ Region of the α1 Subunit
PY Tseng, PB Henderson, AC Hergarden… - Biochemistry, 2017 - ACS Publications
The voltage-gated L-type Ca2+ channel CaV1. 2 is crucial for initiating heartbeat and control
of a number of neuronal functions such as neuronal excitability and long-term potentiation …
of a number of neuronal functions such as neuronal excitability and long-term potentiation …