Controlling the biodistribution and clearance of nanomedicines

H Cabral, J Li, K Miyata, K Kataoka - Nature Reviews Bioengineering, 2024 - nature.com
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …

[HTML][HTML] Liposomes characterization for market approval as pharmaceutical products: Analytical methods, guidelines and standardized protocols.

S Giordani, V Marassi, A Zattoni, B Roda… - … of Pharmaceutical and …, 2023 - Elsevier
Liposomes are nano-sized lipid-based vesicles widely studied for their drug delivery
capabilities. Compared to standard carries they exhibit better properties such as improved …

[HTML][HTML] Towards harmonisation of testing of nanomaterials for EU regulatory requirements on chemical safety–A proposal for further actions

EAJ Bleeker, E Swart, H Braakhuis, MLF Cruz… - Regulatory Toxicology …, 2023 - Elsevier
Over the recent years, EU chemicals legislation, guidance and test guidelines have been
developed or adapted for nanomaterials to facilitate safe use of nanomaterials. This paper …

The Issue of Reliability and Repeatability of Analytical Measurement in Industrial and Academic Nanomedicine

S Sharifi, N Reuel, N Kallmyer, E Sun, MP Landry… - ACS …, 2022 - ACS Publications
The issue of reliability and repeatability of data in the nanomedicine literature is a growing
concern among stakeholders. This perspective discusses the key differences between …

Safety of gold nanoparticles: from in vitro to in vivo testing array checklist

J Lopes, T Ferreira-Gonçalves, L Ascensão, AS Viana… - Pharmaceutics, 2023 - mdpi.com
In recent years, gold nanoparticles (AuNPs) have aroused the interest of many researchers
due to their unique physicochemical and optical properties. AuNPs are being explored in a …

A comparative biodistribution study of polymeric and lipid-based nanoparticles

AKO Åslund, RJ Vandebriel, F Caputo… - Drug Delivery and …, 2022 - Springer
Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the
size, shape, chemical composition and surface properties of the encapsulating nanoparticle …

Nanomedicines and nanocarriers in clinical trials: surfing through regulatory requirements and physico-chemical critical quality attributes

DA Dri, F Rinaldi, M Carafa, C Marianecci - Drug Delivery and …, 2023 - Springer
Elucidation of physical-chemical characteristics of investigational medicinal products should
be established with suitable methodology. Characterization of nanomedicines and …

A review of design criteria for cancer-targeted, nanoparticle-based MRI contrast agents

S Rahmati, AE David - Applied Materials Today, 2024 - Elsevier
Magnetic resonance imaging (MRI) has become an essential tool for the diagnosis and
prognosis of various medical conditions, including cancer. Despite its widespread use, MRI's …

Emerging nano-carrier strategies for brain tumor drug delivery and considerations for clinical translation

DJ Lundy, H Nguyễn, PCH Hsieh - Pharmaceutics, 2021 - mdpi.com
Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents
chemotherapy drugs from reaching the tumor site in sufficient concentrations …

Photodynamic therapy for leishmaniasis: recent advances and future trends

M Varzandeh, R Mohammadinejad… - Photodiagnosis and …, 2021 - Elsevier
Leishmaniasis has infected more than 12 million people worldwide. This neglected tropical
disease, causing 20,000–30,000 deaths per year, is a global health problem. The …