Controlling the biodistribution and clearance of nanomedicines
Nanomedicines improve drug bioavailability, the dose–response relationship, targeting
ability, efficacy and safety compared to conventional freely administered drugs …
ability, efficacy and safety compared to conventional freely administered drugs …
[HTML][HTML] Liposomes characterization for market approval as pharmaceutical products: Analytical methods, guidelines and standardized protocols.
Liposomes are nano-sized lipid-based vesicles widely studied for their drug delivery
capabilities. Compared to standard carries they exhibit better properties such as improved …
capabilities. Compared to standard carries they exhibit better properties such as improved …
[HTML][HTML] Towards harmonisation of testing of nanomaterials for EU regulatory requirements on chemical safety–A proposal for further actions
EAJ Bleeker, E Swart, H Braakhuis, MLF Cruz… - Regulatory Toxicology …, 2023 - Elsevier
Over the recent years, EU chemicals legislation, guidance and test guidelines have been
developed or adapted for nanomaterials to facilitate safe use of nanomaterials. This paper …
developed or adapted for nanomaterials to facilitate safe use of nanomaterials. This paper …
The Issue of Reliability and Repeatability of Analytical Measurement in Industrial and Academic Nanomedicine
The issue of reliability and repeatability of data in the nanomedicine literature is a growing
concern among stakeholders. This perspective discusses the key differences between …
concern among stakeholders. This perspective discusses the key differences between …
Safety of gold nanoparticles: from in vitro to in vivo testing array checklist
J Lopes, T Ferreira-Gonçalves, L Ascensão, AS Viana… - Pharmaceutics, 2023 - mdpi.com
In recent years, gold nanoparticles (AuNPs) have aroused the interest of many researchers
due to their unique physicochemical and optical properties. AuNPs are being explored in a …
due to their unique physicochemical and optical properties. AuNPs are being explored in a …
A comparative biodistribution study of polymeric and lipid-based nanoparticles
Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the
size, shape, chemical composition and surface properties of the encapsulating nanoparticle …
size, shape, chemical composition and surface properties of the encapsulating nanoparticle …
Nanomedicines and nanocarriers in clinical trials: surfing through regulatory requirements and physico-chemical critical quality attributes
DA Dri, F Rinaldi, M Carafa, C Marianecci - Drug Delivery and …, 2023 - Springer
Elucidation of physical-chemical characteristics of investigational medicinal products should
be established with suitable methodology. Characterization of nanomedicines and …
be established with suitable methodology. Characterization of nanomedicines and …
A review of design criteria for cancer-targeted, nanoparticle-based MRI contrast agents
Magnetic resonance imaging (MRI) has become an essential tool for the diagnosis and
prognosis of various medical conditions, including cancer. Despite its widespread use, MRI's …
prognosis of various medical conditions, including cancer. Despite its widespread use, MRI's …
Emerging nano-carrier strategies for brain tumor drug delivery and considerations for clinical translation
DJ Lundy, H Nguyễn, PCH Hsieh - Pharmaceutics, 2021 - mdpi.com
Treatment of brain tumors is challenging since the blood–brain tumor barrier prevents
chemotherapy drugs from reaching the tumor site in sufficient concentrations …
chemotherapy drugs from reaching the tumor site in sufficient concentrations …
Photodynamic therapy for leishmaniasis: recent advances and future trends
M Varzandeh, R Mohammadinejad… - Photodiagnosis and …, 2021 - Elsevier
Leishmaniasis has infected more than 12 million people worldwide. This neglected tropical
disease, causing 20,000–30,000 deaths per year, is a global health problem. The …
disease, causing 20,000–30,000 deaths per year, is a global health problem. The …