Pesticides are unique environmental contaminants that are specifically introduced into the
environment to control pests, often by killing them. Although pesticide application serves …

Background Pyrethroid metabolites are widely detectable in urine from the general
population, including pregnant women and children. Pyrethroids are neurotoxic and …

Pyrethroids are commonly used around the home and in agricultural production to control
insects. Human contact to one or more pyrethroid insecticides is likely. Numerous …

Deltamethrin (DLM) is a Type II pyrethroid pesticide widely used in agriculture, homes,
public spaces, and medicine. Epidemiological studies report that increased pyrethroid …

Exposure to the pyrethroid pesticide deltamethrin has been demonstrated to cause
apoptosis both in vitro and in vivo. However, the molecular pathways leading to deltamethrin …

Introduction Synthetic pyretroids are among the most common pesticides currently used
worldwide. Animal studies suggest that exposure to pyrethroids could dysregulated the …

The free fraction of a xenobiotic in plasma (F ub) is an important determinant of chemical
adsorption, distribution, metabolism, elimination, and toxicity, yet experimental plasma …

Endoplasmic reticulum (ER) stress is implicated as a significant contributor to
neurodegeneration and cognitive dysfunction. Previously, we reported that the widely used …

Endoplasmic reticulum (ER) stress and neuroinflammation are involved in the pathogenesis
of many neurodegenerative disorders. Previously, we reported that exposure to pyrethroid …

To address concerns around age-related sensitivity to pyrethroids, a life-stage
physiologically based pharmacokinetic (PBPK) model, supported by in vitro to in vivo …