The formyl peptide receptors: diversity of ligands and mechanism for recognition

HQ He, RD Ye - Molecules, 2017 - mdpi.com
The formyl peptide receptors (FPRs) are G protein-coupled receptors that transduce
chemotactic signals in phagocytes and mediate host-defense as well as inflammatory …

Antimicrobial activity and DFT studies of a novel set of spiropyrrolidines tethered with thiochroman-4-one/chroman-4-one scaffolds

N Chouchène, A Toumi, S Boudriga, H Edziri, M Sobeh… - Molecules, 2022 - mdpi.com
A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and
oxindole/acenaphthylene-1, 2-dione moieties were synthesized and characterized by …

Flavonoids: from structure to health issues

C Santos-Buelga, AS Feliciano - Molecules, 2017 - mdpi.com
Flavonoids are one of the largest groups of plant secondary metabolites. They are
synthesized through the shikimate/phenylpropanoid and acetate/malonate pathways and …

Light-Driven Two-Step Preparation of 4-Chromanone Fused to Estrone Derivatives

MI Quindt, GF Gola, JA Ramirez… - The Journal of Organic …, 2023 - ACS Publications
A protocol involving the irradiation of some 3-(2-alkenyl) estrone and 3-(2-alkenyl)-17-nor
estrone derivatives under a nitrogen atmosphere in organic solvents (both hexane and …

Design, synthesis, molecular modeling and anticholinesterase activity of benzylidene-benzofuran-3-ones containing cyclic amine side chain

F Mehrabi, Y Pourshojaei, A Moradi… - Future medicinal …, 2017 - Taylor & Francis
Aim: A series of 2-benzylidene-benzofuran-3-ones were designed from the structures of
Ebselen analogs and aurone derivatives and synthesized in good yields. Materials & …

Nickel Catalyzed syn-Selective Aryl Nickelation and Cyclization of Aldehyde/Enone-Tethered Terminal Alkynes with Arylboronic Acids

M Rajesh, MKR Singam, S Puri… - The Journal of …, 2018 - ACS Publications
A syn-arylative nickelation followed by nucleophilic syn-selective cyclization of o-
propargyloxy benzaldehydes is achieved toward the synthesis of chromanol skeletons with …

Enantioselective synthesis of homoisoflavanones by asymmetric transfer hydrogenation and their biological evaluation for antiangiogenic activity

M Heo, B Lee, K Sishtla, X Fei, S Lee… - The Journal of …, 2019 - ACS Publications
Neovascular eye diseases are a major cause of blindness. Excessive angiogenesis is a
feature of several conditions, including wet age-related macular degeneration, proliferative …

Total synthesis of naturally occurring 5, 7, 8-trioxygenated homoisoflavonoids

S Kwon, S Lee, M Heo, B Lee, X Fei, TW Corson… - ACS …, 2020 - ACS Publications
Homoisoflavonoids are in the subclass of the larger family of flavonoids but have one more
alkyl carbon than flavonoids. Among them, 5, 7, 8-trioxygenated homoisoflavonoids have not …

Lewis-acid-catalyzed decarboxylative annulation of 2-aminoindole-3-carboxylate with ynals involving [3+ 2] spirocycloaddition and 2, 3-aza migration

M Rajesh, R Kumar, S Puri, JB Nanubolu… - Organic letters, 2020 - ACS Publications
2-Aminoindole-3-carboxylates undergo a Lewis-acid-catalyzed decarboxylative annulation
with ynals to afford dihydrochromeno-fused δ-carbolines through a 2, 3-aza migration, via a …

Synthesis and Structure Revision of Naturally Occurring Homoisoflavane (+)-Dracaeconolide B

S Kwon, S Lee, J Hur, K Ko, X Fei… - Journal of Natural …, 2022 - ACS Publications
Dracaeconolide B (1), a naturally occurring homoisoflavane, was isolated from the red resin
of Dracaena cochinchinensis. Efforts have been made to elucidate the exact structure of …