Somatic driver mutations in melanoma

BY Reddy, DM Miller, H Tsao - Cancer, 2017 - Wiley Online Library
Melanoma has one of the highest somatic mutational burdens among solid malignancies.
Although the rapid progress in genomic research has contributed immensely to our …

Early detection of acral melanoma: a review of clinical, dermoscopic, histopathologic, and molecular characteristics

CC Darmawan, G Jo, SE Montenegro, Y Kwak… - Journal of the American …, 2019 - Elsevier
Acral lentiginous melanoma is a distinct subtype of melanoma on acral skin. Patient
presentation at later stages and delayed diagnosis by physicians contribute to a worse …

Genetics of metastasis: melanoma and other cancers

N Turner, O Ware, M Bosenberg - Clinical & experimental metastasis, 2018 - Springer
Melanoma is a malignant neoplasm of melanocytes that accounts for the majority of skin
cancer deaths despite comprising less than 5% of all cutaneous malignancies. Its incidence …

[HTML][HTML] Clinicopathological significance of intratumoral and peritumoral lymphocytes and lymphocyte score based on the histologic subtypes of cutaneous melanoma

CK Park, SK Kim - Oncotarget, 2017 - ncbi.nlm.nih.gov
The presence of tumor infiltrating lymphocytes is a favorable prognostic factor in cutaneous
melanoma, but their clinicopathological significance in the intratumoral compartment …

Melanoma genomics: a state‐of‐the‐art review of practical clinical applications

S Guhan, N Klebanov, H Tsao - British Journal of Dermatology, 2021 - academic.oup.com
Our collective understanding of melanoma genomics has rapidly expanded in the past
decade, bringing great promise to patients affected with the most severe and aggressive …

Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma

S Birkeälv, M Harland, LSAS Matsuyama… - The Journal of …, 2023 - Wiley Online Library
Melanoma is a heterogenous malignancy with an unpredictable clinical course. Most
patients who present in the clinic are diagnosed with primary melanoma, yet large‐scale …

Fluorescence in situ hybridisation as an ancillary tool in the diagnosis of acral melanoma: a review of 44 cases

J Su, W Yu, J Liu, J Zheng, S Huang, Y Wang, S Qi… - Pathology, 2017 - Elsevier
Acral melanoma is associated with outcomes which are more unfavourable than those of
other melanoma subtypes, and acral melanoma has higher mortality. However, histological …

Improving the diagnosis and treatment of acral melanocytic lesions

MC Criscito, JA Stein - Melanoma Management, 2017 - Taylor & Francis
Melanocytic lesions of acral sites are common, with an estimated prevalence of 28–36% in
the USA. While the majority of these lesions are benign, differentiation from acral melanoma …

[PDF][PDF] Early detection of subungual melanoma in situ: proposal of ABCD strategy in clinical practice based on case series

JH Lee, JH Park, JH Lee, DY Lee - Annals of dermatology, 2018 - synapse.koreamed.org
Background: Prevalence of subungual melanoma (SUM) in Asian population is relatively
high and early clinical detection improves both quality of life and survival. Objective: We …

[HTML][HTML] A Narrative Review of the Evolution of Diagnostic Techniques and Treatment Strategies for Acral Lentiginous Melanoma

ME Choi, EJ Choi, JM Jung, WJ Lee, YS Jo… - International Journal of …, 2024 - mdpi.com
Acral melanoma (AM) is a subtype of cutaneous melanoma located on the palms, soles, and
nails. The pathogenesis of AM involves mechanical stimulation and characteristic tumor …