Hybrid bilayer membrane (HBM) platforms represent an emerging nanoscale bio-inspired
interface that has broad implications in energy catalysis and smart molecular devices. An …

Current antithrombotic therapies used in clinical settings target either the coagulation
pathways or platelet activation receptors (P2Y12 or GPIIb/IIIa), as well as the …

Thrombosis and its complications are the leading cause of death in patients with diabetes.
Metformin, a first-line therapy for type 2 diabetes, is the only drug demonstrated to reduce …

Platelet thrombus formation includes several integrated processes involving aggregation,
secretion of granules, release of arachidonic acid and clot retraction, but it is not clear which …

Objective—To study the interactions of cytoplasmic calcium elevation, mitochondrial
permeability transition pore (mPTP) formation, and reactive oxygen species formation in the …

Mitochondria are key regulators of cellular energy and redox metabolism, also playing a
central role in cell signaling and death pathways. A number of processes occur within …

Protease‐activated receptors (PARs) are a unique class of G‐protein‐coupled
transmembrane receptors, which revolutionized the perception of proteases from …

Platelets are anucleated cell elements produced by fragmentation of the cytoplasm of
megakaryocytes and have a unique metabolic phenotype compared with circulating …

Platelet activation plays an essential role in the pathogenesis of thrombotic events in
different diseases (eg, cancer, type 2 diabetes, Alzheimer's, and cardiovascular diseases …

BACKGROUND: Single-nucleotide polymorphisms linked with the rs1474868 T allele
(MFN2 [mitofusin-2] T/T) in the human mitochondrial fusion protein MFN2 gene are …