Fragile X mental retardation protein (FMRP) is the product of the fragile X mental retardation
1 gene (FMR1), a gene that—when epigenetically inactivated by a triplet nucleotide repeat …

Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and
neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes …

Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common
cause of inherited intellectual disability, yet it is unknown how FMRP function varies across …

Fragile X messenger ribonucleoprotein 1 protein (FMRP) deficiency leads to fragile X
syndrome (FXS), an autism spectrum disorder. The role of FMRP in prenatal human brain …

Microexons represent the most highly conserved class of alternative splicing, yet their
functions are poorly understood. Here, we focus on closely related neuronal microexons …

Embryonic stem cells (ESCs) and adult stem cells (ASCs) possess the remarkable capacity
to self-renew while remaining poised to differentiate into multiple progenies in the context of …

Transcriptional silencing of the FMR1 gene in fragile X syndrome (FXS) leads to the loss of
the RNA-binding protein FMRP. In addition to regulating mRNA translation and protein …

Silencing of FMR1 and loss of its gene product, FMRP, results in fragile X syndrome (FXS).
FMRP binds brain mRNAs and inhibits polypeptide elongation. Using ribosome profiling of …

Corticogenesis is one of the most critical and complicated processes during embryonic brain
development. Any slight impairment in corticogenesis could cause neurodevelopmental …