The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products

JP Shiau, YT Chuang, JY Tang, KH Yang, FR Chang… - Antioxidants, 2022 - mdpi.com
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

Radical oxygen species: an important breakthrough point for botanical drugs to regulate oxidative stress and treat the disorder of glycolipid metabolism

M Luo, Y Zheng, S Tang, L Gu, Y Zhu, R Ying… - Frontiers in …, 2023 - frontiersin.org
Background: The incidence of glycolipid metabolic diseases is extremely high worldwide,
which greatly hinders people's life expectancy and patients' quality of life. Oxidative stress …

Metabolic changes of active components of important medicinal plants on the basis of traditional Chinese medicine under different environmental stresses

MH Shahrajabian, Y Kuang, H Cui… - Current Organic …, 2023 - benthamdirect.com
Traditional Chinese medicine is an ancient system of wellness and health that has been
used in almost all countries of the world, specially in Asia for thousands of years. The …

Role of the AMPK/SIRT1 pathway in non-alcoholic fatty liver disease

P Anggreini, H Kuncoro… - Molecular medicine …, 2022 - spandidos-publications.com
Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent ailment worldwide.
Moreover, de novo lipogenesis (DNL) is considered a critical factor in the development of …

[HTML][HTML] Identification of heat shock protein family A member 5 (HSPA5) targets involved in nonalcoholic fatty liver disease

A Rehati, B Abuduaini, Z Liang, D Chen, F He - Genes & Immunity, 2023 - nature.com
Heat shock protein family A (Hsp70) member 5 (HSPA5) is an endoplasmic reticulum
chaperone, which regulates cell metabolism, particularly lipid metabolism. While HSPA5's …

Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging

M Matin, T Joshi, D Wang, NT Tzvetkov… - …, 2024 - pmc.ncbi.nlm.nih.gov
Ginger (Zingiber officinale Roscoe) is broadly used as a traditional remedy and food
ingredient, and numerous preclinical and clinical studies have demonstrated health benefits …

Nutraceuticals and the network of obesity modulators

S Ammendola, A Scotto d'Abusco - Nutrients, 2022 - mdpi.com
Obesity is considered an increasingly widespread disease in the world population,
regardless of age and gender. Genetic but also lifestyle-dependent causes have been …

[HTML][HTML] Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in vascular dysfunction

GH Lee, HY Lee, YJ Lim, JH Kim, SJ Jung… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Angelica gigas NAKAI (AG) is a popular traditional medicinal herb widely used to treat
dyslipidemia owing to its antioxidant activity. Vascular disease is intimately linked to obesity …

Natural polyphenols as SERCA activators: Role in the endoplasmic reticulum stress-related diseases

J Viskupicova, P Rezbarikova - Molecules, 2022 - mdpi.com
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) is a key protein responsible for
transporting Ca2+ ions from the cytosol into the lumen of the sarco/endoplasmic reticulum …

10‑Gingerol, a novel ginger compound, exhibits antiadipogenic effects without compromising cell viability in 3T3‑L1 cells

ME Preciado-Ortiz, E Martinez-Lopez… - Biomedical …, 2023 - spandidos-publications.com
Obesity is defined as excessive fat accumulation that can be detrimental to health and
currently affects a large part of the global population. Obesity arises from excessive energy …