Proteins are translated in the cytoplasm, but many need to access the nucleus to perform
their functions. Understanding how these nuclear proteins are transported through the …

Nutrigenomics is an area of epigenomics that explores and defines the rapidly evolving field
of diet-genome interactions. Lifestyle and diet can significantly influence epigenetic …

Summary Histone deacetylase 6 (HDAC6) is a tubulin-specific deacetylase that regulates
microtubule-dependent cell movement. In this study, we identify the F-actin-binding protein …

Poly (ADP-ribose) polymerase 1 (PARP1) and SIRT1 deacetylase are two NAD-dependent
enzymes which play major roles in the decision of a cell to live or to die in a stress situation …

Axonal regenerative failure is a major cause of neurological impairment following central
nervous system (CNS) but not peripheral nervous system (PNS) injury. Notably, PNS injury …

The development and function of neurons require the regulated expression of large
numbers of very specific gene sets. Epigenetic modifications of both DNA and histone …

Reversible posttranslational modification of internal lysines in many cellular or viral proteins
is now emerging as part of critical signalling processes controlling a variety of cellular …

The transcription factor p53 protects neurons from transformation and DNA damage through
the induction of cell‐cycle arrest, DNA repair and apoptosis in a range of in vitro and in vivo …

Mitogen-activated protein kinases (MAPKs) are key regulators of cellular physiology and
immune responses, and abnormalities in MAPKs are implicated in many diseases. MAPKs …

Accumulation of reactive oxygen species (ROS) in skeletal muscles and the resulting
decline in muscle performance are hallmarks of sarcopenia. However, the precise …