Neurocognitive decline following radiotherapy: mechanisms and therapeutic implications

S Pazzaglia, G Briganti, M Mancuso, A Saran - Cancers, 2020 - mdpi.com
The brain undergoes ionizing radiation (IR) exposure in many clinical situations, particularly
during radiotherapy for malignant brain tumors. Cranial radiation therapy is related with the …

Why brain radiation therapy should take account of the individual structural and functional connectivity: Toward an irradiation “à la carte”

H Duffau - Critical Reviews in Oncology/Hematology, 2020 - Elsevier
Although radiation therapy (RT) is a main treatment of brain tumors, delayed cerebral toxicity
may lead to cognitive deteriorations with adverse effects on quality of life. Despite …

Long-term outcomes and late adverse effects of a prospective study on proton radiotherapy for patients with low-grade glioma

S Tabrizi, BY Yeap, JC Sherman, LB Nachtigall… - Radiotherapy and …, 2019 - Elsevier
Background Patients with low-grade gliomas (LGG) can survive years with their illness.
Proton radiotherapy (PRT) can reduce off-target dose and decrease the risk of treatment …

Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review

P Pospisil, L Hynkova, L Hnidakova… - Frontiers in …, 2024 - frontiersin.org
Background The landscape of brain metastases radiotherapy is evolving, with a shift away
from whole-brain radiotherapy (WBRT) toward targeted stereotactic approaches aimed at …

Multifocal high-grade glioma radiotherapy safety and efficacy

DF Fleischmann, R Schön, S Corradini… - Radiation …, 2021 - Springer
Background Multifocal manifestation of high-grade glioma is a rare disease with very
unfavourable prognosis. The pathogenesis of multifocal glioma and pathophysiological …

Memantine in the prevention of radiation-induced brain damage: A narrative review

C Scampoli, S Cammelli, E Galietta, G Siepe… - Cancers, 2022 - mdpi.com
Simple Summary Decline in cognitive function is a major problem for patients undergoing
whole-brain radiotherapy (WBRT). Scientific interest has increased due to the high dropout …

[HTML][HTML] Radiotherapy to the brain: what are the consequences of this age-old treatment?

C Wujanto, B Vellayappan, EL Chang… - Annals of palliative …, 2021 - apm.amegroups.org
Radiotherapy (RT) has been widely used in the management of benign and malignant brain
tumors for decades. However, complications can develop as a result of adjacent structures …

Measuring out-of-field dose to the hippocampus in common radiotherapy indications

H Auerbach, Y Dzierma, M Schürmann, C Rübe… - Radiation …, 2023 - Springer
Background The high susceptibility of the hippocampus region to radiation injury is likely the
causal factor of neurocognitive dysfunctions after exposure to ionizing radiation. Repetitive …

A prospective cohort study of neural progenitor cell-sparing radiation therapy plus temozolomide for newly diagnosed patients with glioblastoma

C Gui, TD Vannorsdall, LR Kleinberg, R Assadi… - …, 2020 - journals.lww.com
BACKGROUND In treating glioblastoma, irradiation of the neural progenitor cell (NPC)
niches is controversial. Lower hippocampal doses may limit neurocognitive toxicity, but …

Automatic segmentation of hippocampus in hippocampal sparing whole brain radiotherapy: A multitask edge‐aware learning

Q Qiu, Z Yang, S Wu, D Qian, J Wei, G Gong… - Medical …, 2021 - Wiley Online Library
Purpose This study aimed to improve the accuracy of the hippocampus segmentation
through multitask edge‐aware learning. Method We developed a multitask framework for …