Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update

M Afarid, S Mahmoodi, R Baghban - Journal of Nanobiotechnology, 2022 - Springer
Ocular drug delivery is one of the most challenging endeavors among the various available
drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic …

Advances in bone marrow stem cell therapy for retinal dysfunction

SS Park, E Moisseiev, G Bauer, JD Anderson… - Progress in retinal and …, 2017 - Elsevier
The most common cause of untreatable vision loss is dysfunction of the retina. Conditions,
such as age-related macular degeneration, diabetic retinopathy and glaucoma remain …

Photoreceptor protection by mesenchymal stem cell transplantation identifies exosomal MiR-21 as a therapeutic for retinal degeneration

CL Deng, CB Hu, ST Ling, N Zhao, LH Bao… - Cell Death & …, 2021 - nature.com
Photoreceptor apoptosis is recognized as one key pathogenesis of retinal degeneration, the
counteraction of which represents a promising approach to safeguard visual function …

Restoring light sensitivity using tunable near-infrared sensors

D Nelidova, RK Morikawa, CS Cowan, Z Raics… - Science, 2020 - science.org
Enabling near-infrared light sensitivity in a blind human retina may supplement or restore
visual function in patients with regional retinal degeneration. We induced near-infrared light …

Gold nanoparticles in ophthalmology

F Masse, M Ouellette, G Lamoureux… - Medicinal research …, 2019 - Wiley Online Library
Many research projects are underway to improve the diagnosis and therapy in
ophthalmology. Indeed, visual acuity deficits affect 285 million people worldwide and …

Cellular reparative mechanisms of mesenchymal stem cells for retinal diseases

SLS Ding, S Kumar, PL Mok - International Journal of Molecular Sciences, 2017 - mdpi.com
The use of multipotent mesenchymal stem cells (MSCs) has been reported as promising for
the treatment of numerous degenerative disorders including the eye. In retinal degenerative …

Management of retinitis pigmentosa by Wharton's jelly derived mesenchymal stem cells: preliminary clinical results

E Özmert, U Arslan - Stem cell research & therapy, 2020 - Springer
Purpose The aim of this study is to determine if umbilical cord Wharton's jelly derived
mesenchymal stem cells implanted in sub-tenon space have beneficial effects on visual …

Management of retinitis pigmentosa by Wharton's jelly-derived mesenchymal stem cells: prospective analysis of 1-year results

E Özmert, U Arslan - Stem cell research & therapy, 2020 - Springer
Purpose The aim of the study was to investigate annual structural and functional results, and
their correlation with inheritance pattern of retinitis pigmentosa (RP) patients who were …

Human Wharton's jelly mesenchymal stem cells protect axotomized rat retinal ganglion cells via secretion of anti-inflammatory and neurotrophic factors

JE Millán-Rivero, FM Nadal-Nicolás… - Scientific Reports, 2018 - nature.com
Mesenchymal stem cell (MSC) transplantation is emerging as an ideal tool to restore the
wounded central nervous system (CNS). MSCs isolated from extra-embryonic tissues have …

Human primitive mesenchymal stem cell-derived retinal progenitor cells improved neuroprotection, neurogenesis, and vision in rd12 mouse model of retinitis …

C Brown, P Agosta, C McKee, K Walker… - Stem Cell Research & …, 2022 - Springer
Background Currently, there is no treatment for retinal degenerative diseases (RDD) such as
retinitis pigmentosa (RP). Stem cell-based therapies could provide promising opportunities …