Next-generation sequencing has revolutionized clinical diagnostic testing. Yet, for a
substantial proportion of patients, sequence information restricted to exons and exon–intron …

The fly Drosophila melanogaster is one of the most intensively studied organisms in biology
and serves as a model system for the investigation of many developmental and cellular …

The removal of non‐coding sequences, introns, from the mRNA precursors is an essential
step in eukaryotic gene expression. U12‐type introns are a minor subgroup of introns …

The genomes of most multicellular organisms contain a new class of introns that have non-
canonical consensus sequences. These minor-class introns occur extremely rarely and are …

Significant advances have been made in elucidating the biogenesis pathway and three-
dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and …

The removal by splicing of introns from the primary transcripts of most mammalian genes is
an essential step in gene expression. Splicing is performed by large, complex …

Mass spectrometry was used to identify novel proteins associated with the human 17S U2
snRNP and one of its stable subunits, SF3b. Several additional proteins were identified …

In this work we review the current knowledge on the prehistory, origins, and evolution of
spliceosomal introns. First, we briefly outline the major features of the different types of …

The splicing factor SF3b is a multiprotein complex essential for the accurate excision of
introns from pre-messenger RNA. As an integral component of the U2 small nuclear …

Each day a cell must face a constant onslaught of DNA lesions. Although we tend to worry
most about environmental sources of DNA damage (eg, chemical agents, UV radiation …