[HTML][HTML] Structural mechanisms of NLRP3 inflammasome assembly and activation

J Fu, H Wu - Annual review of immunology, 2023 - annualreviews.org
As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

[HTML][HTML] IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting

L Broderick, HM Hoffman - Nature Reviews Rheumatology, 2022 - nature.com
Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Cryo-EM structures of the active NLRP3 inflammasome disc

L Xiao, VG Magupalli, H Wu - Nature, 2023 - nature.com
Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

IV Hochheiser, M Pilsl, G Hagelueken, J Moecking… - Nature, 2022 - nature.com
NLRP3 is an intracellular sensor protein that when activated by a broad spectrum of
exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis,. The …

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

H Sharif, L Wang, WL Wang, VG Magupalli, L Andreeva… - Nature, 2019 - nature.com
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid
crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the …

Inflammasome activation and assembly at a glance

A Malik, TD Kanneganti - Journal of cell science, 2017 - journals.biologists.com
Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

[HTML][HTML] NLRP3 inflammasome activation in cancer: a double-edged sword

S Hamarsheh, R Zeiser - Frontiers in immunology, 2020 - frontiersin.org
Inflammation is involved in tumor development and progression as well as antitumor
response to therapy. In the past decade, the crosstalk between inflammation, immunity, and …

[HTML][HTML] Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

A Lu, VG Magupalli, J Ruan, Q Yin, MK Atianand… - Cell, 2014 - cell.com
Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine
maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major …

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

A Stutz, CC Kolbe, R Stahl, GL Horvath… - Journal of Experimental …, 2017 - rupress.org
NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous
danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC …

Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)

AC Bulua, A Simon, R Maddipati, M Pelletier… - Journal of Experimental …, 2011 - rupress.org
Reactive oxygen species (ROS) have an established role in inflammation and host defense,
as they kill intracellular bacteria and have been shown to activate the NLRP3 …