[HTML][HTML] Structural mechanisms of NLRP3 inflammasome assembly and activation
As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …
invasions and endogenous cellular damage and responds by forming the NLRP3 …
[HTML][HTML] IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
L Broderick, HM Hoffman - Nature Reviews Rheumatology, 2022 - nature.com
Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …
monogenic disorders characterized by recurrent fever and systemic inflammation. The …
Cryo-EM structures of the active NLRP3 inflammasome disc
Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
IV Hochheiser, M Pilsl, G Hagelueken, J Moecking… - Nature, 2022 - nature.com
NLRP3 is an intracellular sensor protein that when activated by a broad spectrum of
exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis,. The …
exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis,. The …
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid
crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the …
crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the …
Inflammasome activation and assembly at a glance
A Malik, TD Kanneganti - Journal of cell science, 2017 - journals.biologists.com
Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …
[HTML][HTML] NLRP3 inflammasome activation in cancer: a double-edged sword
S Hamarsheh, R Zeiser - Frontiers in immunology, 2020 - frontiersin.org
Inflammation is involved in tumor development and progression as well as antitumor
response to therapy. In the past decade, the crosstalk between inflammation, immunity, and …
response to therapy. In the past decade, the crosstalk between inflammation, immunity, and …
[HTML][HTML] Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine
maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major …
maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major …
NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
A Stutz, CC Kolbe, R Stahl, GL Horvath… - Journal of Experimental …, 2017 - rupress.org
NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous
danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC …
danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC …
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
AC Bulua, A Simon, R Maddipati, M Pelletier… - Journal of Experimental …, 2011 - rupress.org
Reactive oxygen species (ROS) have an established role in inflammation and host defense,
as they kill intracellular bacteria and have been shown to activate the NLRP3 …
as they kill intracellular bacteria and have been shown to activate the NLRP3 …