As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Inflammation is involved in tumor development and progression as well as antitumor
response to therapy. In the past decade, the crosstalk between inflammation, immunity, and …

Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers,,,–, and NACHT-, leucine-rich repeat …

NLRP3 is an intracellular sensor protein that when activated by a broad spectrum of
exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis,. The …

The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid
crystals, amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the …

Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …

Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine
maturation and cell death. AIM2 and NLRP3 are representative sensor proteins in two major …

NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous
danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC …

Pyrin responds to pathogen signals and loss of cellular homeostasis by forming an
inflammasome complex that drives the cleavage and secretion of interleukin-1β (IL-1β) …