Ensuring that people have access to sufficient and nutritious food is necessary for a healthy
life and the core tenet of food security. With the global population set to reach 9.8 billion by …

Nucleotide metabolism is an essential process in all living organisms. Besides newly
synthesized nucleotides, the recycling (salvage) of partially degraded nucleotides, ie …

Serpentine barrens represent extreme hazards for plant colonists. These sites are
characterized by high porosity leading to drought, lack of essential mineral nutrients, and …

Cofactors are fundamental to the catalytic activity of enzymes. Additionally, because plants
are a critical source of several cofactors (ie, including their vitamin precursors) within the …

NCS 1 proteins are H+/Na+ symporters specific for the uptake of purines, pyrimidines and
related metabolites. In this article, we study the origin, diversification and substrate specificity …

The hydantoin transporter Mhp1 is a sodium‐coupled secondary active transport protein of
the nucleobase‐cation‐symport family and a member of the widespread 5‐helix inverted …

In plants, metabolic homeostasis—the driving force of growth and development—is
achieved through the dynamic behavior of a network of enzymes, many of which depend on …

CodB is a cytosine transporter from the Nucleobase‐Cation‐Symport‐1 (NCS1) transporter
family, a member of the widespread LeuT superfamily. Previous experiments with the …

The recent elucidation of crystal structures of a bacterial member of the NCS1 family, the
Mhp1 benzyl-hydantoin permease from Microbacterium liquefaciens, allowed us to construct …

This work reports the evolutionary relationships, amplified expression, functional
characterization and purification of the putative allantoin transport protein, PucI, from …