Metalloproteinases were first identified as collagen cleaving enzymes and are now
appreciated to play important roles in a wide variety of biological processes. The aberrant …

In the cartilage matrix, complex interactions occur between angiogenic and anti-angiogenic
components, growth factors, and environmental stressors to maintain a proper cartilage …

Matrix metalloproteinase‐13 (MMP‐13) is a uniquely important collagenase that promotes
the irreversible destruction of cartilage collagen in osteoarthritis (OA). Collagenase …

Intra-articular administration of adipose-derived mesenchymal stem cells (ASCs), either in
vitro expanded or within adipose tissue-based products obtained at point-of-care, has …

Osteoarthritis (OA) is the most prevalent joint disorder with increasing worldwide incidence.
Mechanistic insights into OA pathophysiology are evolving and there are currently no …

Serpins (ser ine p roteinase in hibitor s) are an ancient superfamily of structurally similar
proteins, the majority of which use an elegant suicide inhibition mechanism to target serine …

Metalloproteinases remain important players in arthritic disease, in part because members
of this large enzymatic family, namely matrix metalloproteinase-1 (MMP-1) and MMP-13, are …

Cartilage tissue engineering is one of the interesting approaches used for repairing cartilage
injuries. This study reports the fabrication of polyvinyl alcohol/alginate sulfate (PVA/ALG‐S) …

Osteoarthritis (OA) is a chronic degenerative joint disorder primarily affecting the elderly,
characterized by a prominent inflammatory component. The long-term side effects …

This review considers available data on the composition of the extracellular matrix (ECM) in
echinoderms. The connective tissue in these animals has a rather complex organization. It …