Organoids are 3D cell culture systems derived from human pluripotent stem cells that
contain tissue resident cell types and reflect features of early tissue organization. Neural …

Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …

The brain of modern humans has evolved remarkable computational abilities that enable
higher cognitive functions. These capacities are tightly linked to an increase in the size and …

Differential speeds in biochemical reactions have been proposed to be responsible for the
differences in developmental tempo between mice and humans. However, the underlying …

Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and
are evolutionarily significant in general, yet how and why this all-or-nothing transition to …

Progression through fate decisions determines cellular composition and tissue architecture,
but how that same architecture may impact cell fate is less clear. We took advantage of …

Cerebral organoids exhibit broad regional heterogeneity accompanied by limited cortical
cellular diversity despite the tremendous upsurge in derivation methods, suggesting …

Human neural organoids, generated from pluripotent stem cells in vitro, are useful tools to
study human brain development, evolution and disease. However, it is unclear which parts …

Human cerebral organoids, derived from induced pluripotent stem cells, offer a unique in
vitro research window to the development of the cerebral cortex. However, a key player in …