Non-synonymous single nucleotide polymorphisms (nsSNPs) are single base changes
leading to a change to the amino acid sequence of the encoded protein. Many of these …

Large contact surfaces of protein–protein interactions (PPIs) remain to be an ongoing issue
in the discovery and design of small molecule modulators. Peptides are intrinsically capable …

Bar-headed geese (Anser indicus) fly at up to 9,000 m elevation during their migration over
the Himalayas, sustaining high metabolic rates in the severe hypoxia at these altitudes. We …

Malaria and toxoplasmosis are infectious diseases caused by the apicomplexan parasites
Plasmodium and Toxoplasma gondii, respectively. These parasites have developed an …

An essential step in the invasion of red blood cells (RBCs) by Plasmodium falciparum (Pf)
merozoites is the binding of rhoptry neck protein 2 (RON2) to the hydrophobic groove of …

Toyocamycin nitrile hydratase (TNH) is a protein hexamer that catalyzes the hydration of
toyocamycin to produce sangivamycin. The structure of hexameric TNH and the …

Whole-genome duplication (WGD) was experienced twice by the vertebrate ancestor (2
rounds; 2R), again by the teleost fish ancestor (3R) and most recently in certain teleost …

Comparative interactomics is a strategy for inferring potential interactions among
orthologous proteins or “interologs”. Herein we focus, in contrast to standard homology …

Background: Traditional drug discovery approaches focus on a limited set of target
molecules for treatment against specific indications/diseases. However, drug absorption …

The past decade has seen a dramatic expansion in the number and range of techniques
available to obtain genome-wide information and to analyze this information so as to infer …