GRP78 at the centre of the stage in cancer and neuroprotection
C Casas - Frontiers in neuroscience, 2017 - frontiersin.org
The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a
multifunctional protein with activities far beyond its well-known role in the unfolded protein …
multifunctional protein with activities far beyond its well-known role in the unfolded protein …
HSPA5 Gene encoding Hsp70 chaperone BiP in the endoplasmic reticulum
The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family
chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP …
chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP …
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection
AJ Carlos, DP Ha, DW Yeh, R Van Krieken… - Journal of Biological …, 2021 - ASBMB
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
the COVID-19 global pandemic, utilizes the host receptor angiotensin-converting enzyme 2 …
the COVID-19 global pandemic, utilizes the host receptor angiotensin-converting enzyme 2 …
CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells
Developing CAR T cells for acute myeloid leukemia (AML) has been hampered by a paucity
of targets that are expressed on AML blasts and not on hematopoietic progenitor cells …
of targets that are expressed on AML blasts and not on hematopoietic progenitor cells …
Recent insights into the role of unfolded protein response in ER stress in health and disease
Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …
control to maintain homeostasis under different conditions and disease states characterized …
Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells
Coronavirus tropism is predominantly determined by the interaction between coronavirus
spikes and the host receptors. In this regard, coronaviruses have evolved a complicated …
spikes and the host receptors. In this regard, coronaviruses have evolved a complicated …
Glucose‐regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders
The 78 kDa glucose‐regulated protein (GRP78) is an endoplasmic reticulum (ER)‐resident
molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins …
molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins …
[HTML][HTML] Cell surface GRP78: An emerging imaging marker and therapeutic target for cancer
M Farshbaf, AY Khosroushahi, S Mojarad-Jabali… - Journal of Controlled …, 2020 - Elsevier
As one of the deadliest diseases, cancer frequently resists existing therapeutics because
they do not target all cells within a progressing tumor, for example both tumor stem and …
they do not target all cells within a progressing tumor, for example both tumor stem and …
The biological function of the prion protein: a cell surface scaffold of signaling modules
R Linden - Frontiers in molecular neuroscience, 2017 - frontiersin.org
The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …
Endoplasmic reticulum chaperone GRP78 protects heart from ischemia/reperfusion injury through Akt activation
Rationale: Restoration of coronary artery blood flow is the most effective means of
ameliorating myocardial damage triggered by ischemic heart disease. However, coronary …
ameliorating myocardial damage triggered by ischemic heart disease. However, coronary …