[HTML][HTML] A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches
Childhood maltreatment is a major risk factor for chronic and severe mental and physical
health problems across the lifespan. Increasing evidence supports the hypothesis that …
health problems across the lifespan. Increasing evidence supports the hypothesis that …
Cell-type deconvolution from DNA methylation: a review of recent applications
Recent advances in cell-type deconvolution approaches are adding to our understanding of
the biology underlying disease development and progression. DNA methylation (DNAm) …
the biology underlying disease development and progression. DNA methylation (DNAm) …
Traumatic stress and accelerated DNA methylation age: a meta-analysis
Background Recent studies examining the association between posttraumatic stress
disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of …
disorder (PTSD) and accelerated aging, as defined by DNA methylation-based estimates of …
[HTML][HTML] Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans
LC Houtepen, CH Vinkers, T Carrillo-Roa… - Nature …, 2016 - nature.com
DNA methylation likely plays a role in the regulation of human stress reactivity. Here we
show that in a genome-wide analysis of blood DNA methylation in 85 healthy individuals, a …
show that in a genome-wide analysis of blood DNA methylation in 85 healthy individuals, a …
[HTML][HTML] An epigenetic clock for gestational age at birth based on blood methylation data
AK Knight, JM Craig, C Theda, M Bækvad-Hansen… - Genome biology, 2016 - Springer
Background Gestational age is often used as a proxy for developmental maturity by
clinicians and researchers alike. DNA methylation has previously been shown to be …
clinicians and researchers alike. DNA methylation has previously been shown to be …
Differential methylation between ethnic sub-groups reflects the effect of genetic ancestry and environmental exposures
Populations are often divided categorically into distinct racial/ethnic groups based on social
rather than biological constructs. Genetic ancestry has been suggested as an alternative to …
rather than biological constructs. Genetic ancestry has been suggested as an alternative to …
[HTML][HTML] DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
Background Chronic low-grade inflammation reflects a subclinical immune response
implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA …
implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA …
[HTML][HTML] Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-
associated variants from genome-wide association studies (GWAS) may illuminate …
associated variants from genome-wide association studies (GWAS) may illuminate …
[HTML][HTML] Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …
controls. Here, we describe the results of the largest DNA methylation meta-analysis of …
[HTML][HTML] Blood epigenetic age may predict cancer incidence and mortality
Biological measures of aging are important for understanding the health of an aging
population, with epigenetics particularly promising. Previous studies found that tumor tissue …
population, with epigenetics particularly promising. Previous studies found that tumor tissue …