The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

The eukaryotic transcription apparatus synthesizes a staggering diversity of RNA molecules.
The labour of nuclear gene transcription is, therefore, divided among multiple DNA …

Abstract RNA Polymerase (Pol) I produces ribosomal (r) RNA, an essential component of the
cellular protein synthetic machinery that drives cell growth, underlying many fundamental …

NusG homologs regulate transcription and coupled processes in all living organisms. The
Escherichia coli (E. coli) two-domain paralogs NusG and RfaH have conformationally …

The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the
cell cycle. It phosphorylates several key proteins to control progression through the different …

Ribosome biogenesis is a highly regulated, essential cellular process. Although studies in
yeast have established some of the biological principles of ribosome biogenesis, many of …

Transcriptional riboswitches involve RNA aptamers that are typically found in the 5′
untranslated regions (UTRs) of bacterial mRNAs and form alternative secondary structures …

Angiogenin (ANG) is a secreted ribonuclease best known for its ability to promote formation
of blood vessels. Extensive research over many years has elucidated its structure and …

In all domains of life, elongating RNA polymerases require the assistance of accessory
factors to maintain their processivity and regulate their rate. Among these elongation factors …

Spt5 is the only known RNA polymerase-associated factor that is conserved in all three
domains of life. We have solved the structure of the Methanococcus jannaschii Spt4/5 …