Conditioned place preference (CPP) continues to be one of the most popular models to
study the motivational effects of drugs and non‐drug treatments in experimental animals …

Drug addiction is a chronic disorder characterized by a high rate of relapse following
detoxification. There are two main versions of the reinstatement model that are employed to …

Background: Cocaine dependence is an important problem without any effective
pharmacological treatment. Some preclinical studies have suggested that cannabidiol …

The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and
emotional behaviors. OXT plays a role in stress response and in drug reward, but to date no …

The experience of social stress during adolescence is associated with higher vulnerability to
drug use. Increases in the acquisition of cocaine self-administration, in the escalation of …

Rationale Drug addiction is a multifactorial disorder resulting from an interaction between
genetic and environmental factors, and negative and positive environmental conditions may …

Rationale Repeated social defeat (RSD) increases the rewarding effects of cocaine in
adolescent and adult rodents. Objective The aim of the present study was to compare the …

Binge eating is a specific form of overeating characterized by intermittent excessive eating.
In addition to altering the neurobiological reward system, several studies have highlighted …

Novelty-seeking in rodents, defined as enhanced specific exploration of novel situations, is
considered to predict the response of animals to drugs of abuse and, thus, identify “drug …

The lipid-derived messenger oleoylethanolamide (OEA) has been involved in multiple
physiological functions including metabolism and the immune response. More recently, OEA …