Gangliosides are the main glycolipids of neuronal plasma membranes. Their surface
patterns are generated by coordinated processes, involving biosynthetic pathways of the …

GM2 gangliosidoses are a group of pathologies characterized by GM2 ganglioside
accumulation into the lysosome due to mutations on the genes encoding for the β …

Sphingolipids and glycosphingolipids are membrane components of eukaryotic cell
surfaces. Their constitutive degradation takes place on the surface of intra-endosomal and …

Human diseases caused by alterations in the metabolism of sphingolipids or
glycosphingolipids are mainly disorders of the degradation of these compounds. The …

The post-translational modification of serine and threonine residues ofnucleocytoplasmic
proteins with 2-acetamido-2-deoxy-d-glucopyranose (GlcNAc) is a reversible process …

Gangliosides are sialic acid‐containing glycosphingolipids. They occur especially on the
cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in …

Tay-Sachs disease belongs to the group of autosomal-recessive lysosomal storage
metabolic disorders. This disease is caused by β-hexosaminidase A (HexA) enzyme …

Bacteria in a biofilm are enmeshed in a self-synthesized extracellular polysaccharide matrix
that holds the bacteria together in a mass and firmly attaches the bacterial mass to the …

β-N-Acetylhexosaminidases (EC 3.2. 1.52, belonging to CAZy GH families 3, 20 and 84)
have recently gained a lot of attention, not only due to their implication in human physiology …

Endocytosed (glyco) sphingolipids are degraded, together with other membrane lipids in a
stepwise fashion by endolysosomal enzymes with the help of small lipid binding proteins …