When the production of reactive oxygen species (ROS) is overloaded surpassing the
capacity of the reductive rheostat, mammalian cells undergo a series of oxidative damage …

Haemostasis stops bleeding at the site of vascular injury and maintains the integrity of blood
vessels through clot formation. This regulated physiological process consists of complex …

Variations in platelet number, volume, and function are largely genetically controlled, and
many loci associated with platelet traits have been identified by genome-wide association …

Platelet function testing is essential for the diagnosis of hemostasis disorders. While there
are many methods used to test platelet function for research purposes, standardization is …

Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of
vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for …

Platelet-rich plasma (PRP) is an autologous platelet concentrate prepared from the whole
blood that is activated to release growth factors (GFs) and cytokines and has been shown to …

Hermansky–Pudlak syndrome (HPS) is a rare autosomal recessive genetic disorder
characterized by oculocutaneous albinism and a bleeding diathesis due to platelet …

Background Less than 50 patients with FPD/AML (OMIM 601309) have been reported as of
today and there may an underestimation. The purpose of this study was to describe the …

Flow cytometry is increasingly used in the study of platelets in inherited and acquired
disorders of platelet number and function. However, wide variation exists in specific …

Platelet dense-granules are small organelles specific to the platelet lineage that contain
small molecules (calcium, adenyl nucleotides, serotonin) and are essential for the activation …