Emerging roles and functional mechanisms of PIWI-interacting RNAs
X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
Specification and epigenetic programming of the human germ line
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
[PDF][PDF] A single mechanism of biogenesis, initiated and directed by PIWI proteins, explains piRNA production in most animals
In animals, PIWI-interacting RNAs (piRNAs) guide PIWI proteins to silence transposons and
regulate gene expression. The mechanisms for making piRNAs have been proposed to …
regulate gene expression. The mechanisms for making piRNAs have been proposed to …
Differential expression of human tRNA genes drives the abundance of tRNA-derived fragments
AG Torres, O Reina… - Proceedings of the …, 2019 - National Acad Sciences
The human genome encodes hundreds of transfer RNA (tRNA) genes but their individual
contribution to the tRNA pool is not fully understood. Deep sequencing of tRNA transcripts …
contribution to the tRNA pool is not fully understood. Deep sequencing of tRNA transcripts …
piRNAs and PIWI proteins: regulators of gene expression in development and stem cells
P Rojas-Ríos, M Simonelig - Development, 2018 - journals.biologists.com
ABSTRACT PIWI proteins and Piwi-interacting RNAs (piRNAs) have established and
conserved roles in repressing transposable elements (TEs) in the germline of animals …
conserved roles in repressing transposable elements (TEs) in the germline of animals …
[HTML][HTML] The biogenesis and functions of piRNAs in human diseases
X Wu, Y Pan, Y Fang, J Zhang, M Xie, F Yang… - … Therapy-Nucleic Acids, 2020 - cell.com
Piwi-interacting RNAs (piRNAs) are a novel type of small noncoding RNAs, which are 26–30
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …
nt in length and bind to Piwi proteins. These short RNAs were originally discovered in …
[HTML][HTML] The emergence of piRNAs against transposon invasion to preserve mammalian genome integrity
Transposable elements (TEs) contribute to the large amount of repetitive sequences in
mammalian genomes and have been linked to species-specific genome innovations by …
mammalian genomes and have been linked to species-specific genome innovations by …
[HTML][HTML] Roles of noncoding RNA in reproduction
C He, K Wang, Y Gao, C Wang, L Li, Y Liao, K Hu… - Frontiers in …, 2021 - frontiersin.org
The World Health Organization predicts that infertility will be the third major health threat
after cancer and cardiovascular disease, and will become a hot topic in medical research …
after cancer and cardiovascular disease, and will become a hot topic in medical research …
[HTML][HTML] Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes
Small RNAs have important functions. However, small RNAs in primate oocytes remain
unexplored. Herein, we develop CAS-seq, a single-cell small RNA sequencing method, and …
unexplored. Herein, we develop CAS-seq, a single-cell small RNA sequencing method, and …
Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans
In the fetal mouse testis, PIWI-interacting RNAs (piRNAs) guide PIWI proteins to silence
transposons but, after birth, most post-pubertal pachytene piRNAs map to the genome …
transposons but, after birth, most post-pubertal pachytene piRNAs map to the genome …