Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

In general perturbation methods starts with a known exact solution of a problem and add
“small” variation terms in order to approach to a solution for a related problem without known …

Predicting protein subcellular localization is an important and difficult problem, particularly
when query proteins may have the multiplex character, ie, simultaneously exist at, or move …

The use of Cheminformatics tools is gaining importance in the field of translational research
from Medicinal Chemistry to Neuropharmacology. In particular, we need it for the analysis of …

Many drugs with very different affinity to a large number of receptors are described. Thus, in
this work, we selected drug− target pairs (DTPs/nDTPs) of drugs with high affinity/nonaffinity …

Pharmaceuticals being extensively and progressively used in human and veterinary
medicine are emerging as significant environmental contaminants. Pharmaceuticals are …

The interest on computational techniques for the discovery of neuroprotective drugs has
increased due to recent fail of important clinical trials. In fact, there is a huge amount of data …

Extended topochemical atom (ETA) indices developed by our group have been extensively
applied in our previous reports for toxicity and ecotoxicity modelling in the field of …

Plasmodium falciparum, Leishmania, Trypanosomes, are the causers of diseases such as
malaria, leishmaniasis and African trypanosomiasis that nowadays are the most serious …

The disappointing results obtained in recent clinical trials renew the interest in experimental/
computational techniques for the discovery of neuroprotective drugs. In this context …