BACKGROUND Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in
their function leading to decreased insulin secretion or may arise from insulin resistance and …

Obesity and metabolic syndrome (MetS) are global epidemics, driven by an obesogenic
environment. This is mediated by complex underlying pathophysiology, in which chronic …

Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …

In men with type 2 diabetes mellitus (T2DM), steroidogenesis and spermatogenesis are
impaired. Metformin and the agonists of luteinizing hormone/human chorionic gonadotropin …

Initially produced in Europe in 1958, metformin is still one of the most widely prescribed
drugs to treat type II diabetes and other comorbidities associated with insulin resistance …

Vitamins and minerals serve essential roles in cellular metabolism, maintenance and growth
throughout life. They are also central components of many enzymes and transcription …

Background/Aims. Obesity, which is related to increased oxidative stress in various tissues,
is a risk factor for male infertility. Metformin is reported to have an antioxidant effect; …

Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up
to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and …

Diabetes mellitus (DM) is one of the most prevalent chronic diseases and has been a
leading cause of death in the last decades. Thus, methods to detect, prevent or delay this …

Context: Metformin's effect on glycaemic control is well documented, but its effect on
diabetes-induced testicular impairment has been scarcely reported. Objective: To …