Therapeutic cancer vaccines are designed to increase tumor-specific T cell immunity.
However, suppressive mechanisms within the tumor microenvironment (TME) may limit T …

Spatial and molecular characteristics determine tissue function, yet high-resolution methods
to capture both concurrently are lacking. Here, we developed high-definition spatial …

Background The primary issue arising from prostate cancer (PCa) is its high prevalence to
metastasize to bone, which severely affects the quality of life and survival time of PCa …

Breast cancer is an individually unique, multi-faceted and chameleonic disease, an eternal
challenge for the new era of high-integrated precision diagnostic and personalized …

Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar)
histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but …

Background Anti-angiogenic therapy represents a promising strategy for non-small-cell lung
cancer (NSCLC) but its application in lung squamous cell carcinoma (SQC) is limited due to …

Breast cancer metastasis is a complex, multi-step process, with high cellular heterogeneity
between primary and metastatic breast cancer, and more complex interactions between …

A number of studies have reported that aberrant expression of microRNAs (miRNAs) closely
correlates with the bone metastasis of prostate cancer (PCa). However, clinical significance …

Abstract Background Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize
to bone. miR-141-3p is an extensively studied miRNA in cancers and downregulation of miR …

Autoimmune thyroid diseases (AITD) such as Graves' disease (GD) or Hashimoto's
thyroiditis (HT) are organ-specific diseases that involve complex interactions between …