Protein–protein interactions (PPIs) participate in all important biological processes in living
organisms, such as catalyzing metabolic reactions, DNA replication, DNA transcription …

Translating data to knowledge and actionable insights is the Holy Grail for many scientific
fields, including biology. The unprecedented massive and heterogeneous data have created …

Proteins are central to all of the processes of life. For their activity, they almost invariably
need to interact with other macromolecules, be they nucleic acids, membranes, glycans, or …

Protein-protein interaction networks are one of the most effective representations of cellular
behavior. In order to build these models, high-throughput techniques are required. Next …

The circadian clock drives daily rhythms of many plant physiological responses, providing a
competitive advantage that improves plant fitness and survival rates [1–5]. Whereas multiple …

BACKGROUND Deciphering the function of the many genes previously classified as
uncharacterized open reading frame (ORF) would complete our understanding of a cell's …

Mapping protein–protein interactions at a proteome scale is critical to understanding how
cellular signaling networks respond to stimuli. Since eukaryotic genomes encode thousands …

The barley powdery mildew fungus, Blumeria hordei (Bh), secretes hundreds of candidate
secreted effector proteins (CSEPs) to facilitate pathogen infection and colonization. One of …

Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human
pathogens causing around 100 million symptomatic infections each year. During infection …

Interactions between proteins are fundamental for every biological process and especially
important in cell signaling pathways. Biochemical techniques that evaluate these protein …