High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Review of wearable technologies and machine learning methodologies for systematic detection of mild traumatic brain injuries

W Schmid, Y Fan, T Chi, E Golanov… - Journal of neural …, 2021 - iopscience.iop.org
Mild traumatic brain injuries (mTBIs) are the most common type of brain injury. Timely
diagnosis of mTBI is crucial in making'go/no-go'decision in order to prevent repeated injury …

Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes

Z Jahed, Y Yang, CT Tsai, EP Foster… - Nature …, 2022 - nature.com
Drug-induced cardiotoxicity arises primarily when a compound alters the
electrophysiological properties of cardiomyocytes. Features of intracellular action potentials …

Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level

X Yuan, M Schröter, MEJ Obien, M Fiscella… - Nature …, 2020 - nature.com
Chronic imaging of neuronal networks in vitro has provided fundamental insights into
mechanisms underlying neuronal function. Current labeling and optical imaging methods …

A 1024-channel simultaneous recording neural SoC with stimulation and real-time spike detection

DY Yoon, S Pinto, SW Chung, P Merolla… - 2021 Symposium on …, 2021 - ieeexplore.ieee.org
A fully implantable brain-machine interface (BMI) targeting clinical applications has stringent
size and power requirements. In this paper we present a 5× 4mm 2 neural system-on-chip …

High-density electrical recording and impedance imaging with a multi-modal CMOS multi-electrode array chip

B Miccoli, CM Lopez, E Goikoetxea, J Putzeys… - Frontiers in …, 2019 - frontiersin.org
Multi-electrode arrays, both active or passive, emerged as ideal technologies to unveil
intricated electrophysiological dynamics of cells and tissues. Active MEAs, designed using …

Development of in vitro 2D and 3D microelectrode arrays and their role in advancing biomedical research

CM Didier, A Kundu, D DeRoo… - … of Micromechanics and …, 2020 - iopscience.iop.org
The development of microelectrode arrays (MEAs) along with complementary advances in
electronics, mechanics and software to connect with these arrays has led to the in vitro …

The next generation of hybrid microfluidic/integrated circuit chips: recent and upcoming advances in high-speed, high-throughput, and multifunctional lab-on-IC …

V Iyer, DA Issadore, F Aflatouni - Lab on a Chip, 2023 - pubs.rsc.org
Since the field's inception, pioneers in microfluidics have made significant progress towards
realizing complete lab-on-chip systems capable of sophisticated sample analysis and …

Large‐Area Field Potential Imaging Having Single Neuron Resolution Using 236 880 Electrodes CMOS‐MEA Technology

I Suzuki, N Matsuda, X Han, S Noji… - Advanced …, 2023 - Wiley Online Library
The electrophysiological technology having a high spatiotemporal resolution at the single‐
cell level and noninvasive measurements of large areas provide insights on underlying …

Extracellular recording of entire neural networks using a dual-mode microelectrode array with 19 584 electrodes and high SNR

X Yuan, A Hierlemann, U Frey - IEEE journal of solid-state …, 2021 - ieeexplore.ieee.org
Electrophysiological research on neural networks and their activity focuses on the recording
and analysis of large data sets that include information of thousands of neurons. CMOS …