[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers

J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Dissolution mechanisms of amorphous solid dispersions: A close look at the dissolution interface

A Deac, Q Qi, AS Indulkar, Y Gao… - Molecular …, 2023 - ACS Publications
Despite the recent success of amorphous solid dispersions (ASDs) at enabling the delivery
of poorly soluble small molecule drugs, ASD-based dosage forms are limited by low drug …

Drug release from surfactant-containing amorphous solid dispersions: mechanism and role of surfactant in release enhancement

R Yang, GGZ Zhang, DY Zemlyanov, HS Purohit… - Pharmaceutical …, 2023 - Springer
Purpose To understand how surfactants affect drug release from ternary amorphous solid
dispersions (ASDs), and to investigate different mechanisms of release enhancement …

Formulation strategies for the development of high drug-loaded amorphous solid dispersions

H Mamidi, S Palekar, H Patel, PK Nukala, K Patel - Drug Discovery Today, 2023 - Elsevier
Amorphous solid dispersions (ASD) have gained tremendous attention over the past two
decades as one of the most promising techniques for enhancing the solubility of poorly …

[HTML][HTML] Thermodynamic modeling of the amorphous solid dispersion-water interfacial layer and its impact on the release mechanism

S Dohrn, SO Kyeremateng, E Bochmann, E Sobich… - Pharmaceutics, 2023 - mdpi.com
During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …

Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability

D Yu, H Nie, SW Hoag - International Journal of Pharmaceutics, 2024 - Elsevier
Amorphous solid dispersion (ASD) is a well-established strategy for enhancing the solubility
and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet …

[HTML][HTML] Insights into the Mechanism of Enhanced Dissolution in Solid Crystalline Formulations

A Justen, G Schaldach, M Thommes - Pharmaceutics, 2024 - mdpi.com
Solid dispersions are a promising approach to enhance the dissolution of poorly water-
soluble drugs. Solid crystalline formulations show a fast drug dissolution and a high …

Interplay of Drug–Polymer Interactions and Release Performance for HPMCAS-Based Amorphous Solid Dispersions

P Bapat, S Paul, YC Tseng, LS Taylor - Molecular Pharmaceutics, 2024 - ACS Publications
The interplay between drug and polymer chemistry and its impact on drug release from an
amorphous solid dispersion (ASD) is a relatively underexplored area. Herein, the release …

Dissolution Mechanisms of Amorphous Solid Dispersions: Application of Ternary Phase Diagrams To Explain Release Behavior

A Deac, C Luebbert, Q Qi, RM Courtney… - Molecular …, 2024 - ACS Publications
The use of amorphous solid dispersions (ASDs) in commercial drug products has increased
in recent years due to the large number of poorly soluble drugs in the pharmaceutical …

Kinetic and Thermodynamic Interplay of Polymer-Mediated Liquid–Liquid Phase Separation for Poorly Water-Soluble Drugs

K Qian, L Stella, F Liu, DS Jones… - Molecular …, 2024 - ACS Publications
Understanding the interplay between kinetics and thermodynamics of polymer-mediated
liquid–liquid phase separation is crucial for designing and implementing an amorphous …