[HTML][HTML] Advances in the development of amorphous solid dispersions: The role of polymeric carriers
J Zhang, M Guo, M Luo, T Cai - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …
Dissolution mechanisms of amorphous solid dispersions: A close look at the dissolution interface
Despite the recent success of amorphous solid dispersions (ASDs) at enabling the delivery
of poorly soluble small molecule drugs, ASD-based dosage forms are limited by low drug …
of poorly soluble small molecule drugs, ASD-based dosage forms are limited by low drug …
Drug release from surfactant-containing amorphous solid dispersions: mechanism and role of surfactant in release enhancement
Purpose To understand how surfactants affect drug release from ternary amorphous solid
dispersions (ASDs), and to investigate different mechanisms of release enhancement …
dispersions (ASDs), and to investigate different mechanisms of release enhancement …
Formulation strategies for the development of high drug-loaded amorphous solid dispersions
Amorphous solid dispersions (ASD) have gained tremendous attention over the past two
decades as one of the most promising techniques for enhancing the solubility of poorly …
decades as one of the most promising techniques for enhancing the solubility of poorly …
[HTML][HTML] Thermodynamic modeling of the amorphous solid dispersion-water interfacial layer and its impact on the release mechanism
S Dohrn, SO Kyeremateng, E Bochmann, E Sobich… - Pharmaceutics, 2023 - mdpi.com
During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …
Comprehensive evaluation of polymer types and ratios in Spray-Dried Dispersions: Compaction, Dissolution, and physical stability
Amorphous solid dispersion (ASD) is a well-established strategy for enhancing the solubility
and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet …
and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet …
[HTML][HTML] Insights into the Mechanism of Enhanced Dissolution in Solid Crystalline Formulations
A Justen, G Schaldach, M Thommes - Pharmaceutics, 2024 - mdpi.com
Solid dispersions are a promising approach to enhance the dissolution of poorly water-
soluble drugs. Solid crystalline formulations show a fast drug dissolution and a high …
soluble drugs. Solid crystalline formulations show a fast drug dissolution and a high …
Interplay of Drug–Polymer Interactions and Release Performance for HPMCAS-Based Amorphous Solid Dispersions
The interplay between drug and polymer chemistry and its impact on drug release from an
amorphous solid dispersion (ASD) is a relatively underexplored area. Herein, the release …
amorphous solid dispersion (ASD) is a relatively underexplored area. Herein, the release …
Dissolution Mechanisms of Amorphous Solid Dispersions: Application of Ternary Phase Diagrams To Explain Release Behavior
A Deac, C Luebbert, Q Qi, RM Courtney… - Molecular …, 2024 - ACS Publications
The use of amorphous solid dispersions (ASDs) in commercial drug products has increased
in recent years due to the large number of poorly soluble drugs in the pharmaceutical …
in recent years due to the large number of poorly soluble drugs in the pharmaceutical …
Kinetic and Thermodynamic Interplay of Polymer-Mediated Liquid–Liquid Phase Separation for Poorly Water-Soluble Drugs
K Qian, L Stella, F Liu, DS Jones… - Molecular …, 2024 - ACS Publications
Understanding the interplay between kinetics and thermodynamics of polymer-mediated
liquid–liquid phase separation is crucial for designing and implementing an amorphous …
liquid–liquid phase separation is crucial for designing and implementing an amorphous …