Host cell proteases: critical determinants of coronavirus tropism and pathogenesis
JK Millet, GR Whittaker - Virus research, 2015 - Elsevier
Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses
that infect a wide range of avian and mammalian species, including humans. The …
that infect a wide range of avian and mammalian species, including humans. The …
[HTML][HTML] Physiological and molecular triggers for SARS-CoV membrane fusion and entry into host cells
JK Millet, GR Whittaker - Virology, 2018 - Elsevier
During viral entry, enveloped viruses require the fusion of their lipid envelope with host cell
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
membranes. For coronaviruses, this critical step is governed by the virally-encoded spike (S) …
[HTML][HTML] Coronavirus entry: how we arrived at SARS-CoV-2
Because of the COVID-19 pandemic, the novel coronavirus SARS-CoV-2 has risen to shape
scientific research during 2020, with its spike (S) protein being a predominant focus. The S …
scientific research during 2020, with its spike (S) protein being a predominant focus. The S …
HIV virions sense plasma membrane heterogeneity for cell entry
ST Yang, AJB Kreutzberger, V Kiessling… - Science …, 2017 - science.org
It has been proposed that cholesterol in host cell membranes plays a pivotal role for cell
entry of HIV. However, it remains largely unknown why virions prefer cholesterol-rich …
entry of HIV. However, it remains largely unknown why virions prefer cholesterol-rich …
Supramolecular architecture of the coronavirus particle
BW Neuman, MJ Buchmeier - Advances in virus research, 2016 - Elsevier
Coronavirus particles serve three fundamentally important functions in infection. The virion
provides the means to deliver the viral genome across the plasma membrane of a host cell …
provides the means to deliver the viral genome across the plasma membrane of a host cell …
Imaging, tracking and computational analyses of virus entry and egress with the cytoskeleton
Viruses have a dual nature: particles are “passive substances” lacking chemical energy
transformation, whereas infected cells are “active substances” turning-over energy. How …
transformation, whereas infected cells are “active substances” turning-over energy. How …
Production of pseudotyped particles to study highly pathogenic coronaviruses in a biosafety level 2 setting
The protocol aims to generate coronavirus (CoV) spike (S) fusion protein pseudotyped
particles with a murine leukemia virus (MLV) core and luciferase reporter, using a simple …
particles with a murine leukemia virus (MLV) core and luciferase reporter, using a simple …
Functional infectious nanoparticle detector: Finding viruses by detecting their host entry functions using organic bioelectronic devices
Emerging viruses will continue to be a threat to human health and wellbeing into the
foreseeable future. The COVID-19 pandemic revealed the necessity for rapid viral sensing …
foreseeable future. The COVID-19 pandemic revealed the necessity for rapid viral sensing …
[HTML][HTML] Engineering a model to study viral infections: bioprinting, microfluidics, and organoids to defeat coronavirus disease 2019 (COVID-19)
While the number of studies related to severe acute respiratory syndrome-related
coronavirus 2 (SARS-CoV-2) is constantly growing, it is essential to provide a framework of …
coronavirus 2 (SARS-CoV-2) is constantly growing, it is essential to provide a framework of …
Membrane protein mobility and orientation preserved in supported bilayers created directly from cell plasma membrane blebs
MJ Richards, CY Hsia, RR Singh, H Haider, J Kumpf… - Langmuir, 2016 - ACS Publications
Membrane protein interactions with lipids are crucial for their native biological behavior, yet
traditional characterization methods are often carried out on purified protein in the absence …
traditional characterization methods are often carried out on purified protein in the absence …