Messenger RNA (mRNA)-based therapeutic agents have demonstrated significant potential
in recent times, particularly in the context of the COVID-19 pandemic outbreak. As a …

Therapeutics utilizing siRNA are currently limited by the availability of safe and effective
delivery systems. Cutaneous diseases, specifically ones with significant genetic components …

Lipid‐based nanoparticles have recently shown great promise, establishing themselves as
the gold standard in delivering novel RNA therapeutics. However, research on the effects of …

Introduction Loss of the cystic fibrosis transmembrane conductance regulator in cystic
fibrosis (CF) leads to hyperabsorption of sodium and fluid from the airway due to …

The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium
hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and …

There is increasing evidence that the Myocardin-related transcription factor/Serum response
factor (MRTF/SRF) pathway plays a key role in fibroblast activation and that knocking down …

RNA interference induced by double-stranded, small interfering RNA (siRNA) molecules has
attracted great attention as a naturally-occurring approach to silence gene expression with …

We developed an anticancer siRNA delivery system (named HLPR) through modular
assembly of endogenous molecules. The structure of HLPR was a tightly condensed siRNA …

Cellulose nanomaterials (CNMs) are typically produced in aqueous suspensions at low
concentrations, which require subsequent dewatering to reduce transportation cost or as a …

One of the greatest challenges for the development of genetic therapies is the efficient
targeted delivery of therapeutic nucleic acids. Towards this goal, we have introduced a new …