Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Resolving-type macrophages prevent chronic inflammation by clearing apoptotic cells
through efferocytosis. These macrophages are thought to rely mainly on oxidative …

Efferocytosis inhibition is emerging as an attractive strategy for antitumor immune therapy
because of the subsequent leak of abundant immunogenic contents. However, the practical …

Pain imposes a significant urden on patients, affecting them physically, psychologically, and
economically. Despite numerous studies on the pathogenesis of pain, its clinical …

The clearance of apoptotic cells, termed efferocytosis, is essential for tissue homeostasis
and prevention of autoimmunity. Although past studies have elucidated local molecular …

Cancers are genetically driven, rogue tissues which generate dysfunctional, obdurate
organs by hijacking normal, homeostatic programs. Apoptosis is an evolutionarily conserved …

Selectively labeling cells with damaged membranes is needed not only for identifying dead
cells in culture, but also for imaging membrane barrier dysfunction in pathologies in vivo …

Ferroptosis is a distinct form of necrotic cell death caused by overwhelming lipid
peroxidation, and emerging evidence indicates a major contribution to organ damage in …

Increased apoptosis of alveolar epithelial cells is a prominent feature of pulmonary fibrosis.
Macrophage efferocytosis, phagocytosis of apoptotic cells by macrophages, is crucial for …