Hemes remain one of the most visible and versatile classes of cofactors utilized in biology. 1
Since their discovery, the structural and functional aspects of heme proteins have fascinated …

The highly contagious disease tuberculosis (TB) is caused by the bacterium Mycobacterium
tuberculosis (Mtb), which has been evolving drug resistance at an alarming rate. Like all …

This is the second set of Handbook of Porphyrin Science. Porphyrins, phthalocyanines and
their numerous analogues and derivatives are materials of tremendous importance in …

For cancer cells to survive and proliferate, they must escape normal immune destruction.
One mechanism by which this is accomplished is through immune suppression effected by …

Labile heme (LH) is a complex of Fe (II) and protoporphyrin IX, an essential signaling
molecule in various biological systems. Most of the subcellular dynamics of LH remain …

Communication between cellular compartments is vital for development and environmental
adaptation. Signals emanating from organelles, so-called retrograde signals, coordinate …

Heme serves as a co-factor in proteins involved in fundamental biological processes
including oxidative metabolism, oxygen storage and transport, signal transduction and drug …

Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with
biological membranes. The very same properties of heme that nature exploits to support life …

Nature has evolved an optimal synthetic factory in the form of translational and
posttranslational processes by which millions of proteins with defined primary sequences …

Porphyromonas gingivalis, a main etiologic agent and key pathogen responsible for
initiation and progression of chronic periodontitis requires heme as a source of iron and …