[HTML][HTML] DNA repair targeted therapy: The past or future of cancer treatment?
NS Gavande, PS VanderVere-Carozza… - Pharmacology & …, 2016 - Elsevier
The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …
remedy specific types of damage to DNA. The range of insults to DNA includes small …
Small molecules, inhibitors of DNA-PK, targeting DNA repair, and beyond
D Davidson, L Amrein, L Panasci… - Frontiers in pharmacology, 2013 - frontiersin.org
Many current chemotherapies function by damaging genomic DNA in rapidly dividing cells
ultimately leading to cell death. This therapeutic approach differentially targets cancer cells …
ultimately leading to cell death. This therapeutic approach differentially targets cancer cells …
Phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring
M Andrs, J Korabecny, D Jun, Z Hodny… - Journal of medicinal …, 2015 - ACS Publications
Phosphatidylinositol 3-kinases (PI3Ks) and phosphatidylinositol 3-kinase-related protein
kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell …
kinases (PIKKs) are two related families of kinases that play key roles in regulation of cell …
Medicinal chemistry of oxazines as promising agents in drug discovery
Oxazines have brought much synthetic interest due to their extensive biological activities.
These are the important category of heterocycles, which may be formally derived from …
These are the important category of heterocycles, which may be formally derived from …
Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising
The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to
ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell's genetic …
ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell's genetic …
Development and therapeutic potential of DNA-dependent protein kinase inhibitors
Z Hui, H Deng, X Zhang, C Garrido, F Lirussi, XY Ye… - Bioorganic …, 2024 - Elsevier
The deployment of DNA damage response (DDR) combats various forms of DNA damage,
ensuring genomic stability. Cancer cells' propensity for genomic instability offers therapeutic …
ensuring genomic stability. Cancer cells' propensity for genomic instability offers therapeutic …
Rational design, synthesis, pharmacophore modeling, and docking studies for identification of novel potent DNA-PK inhibitors
Drugs of cancer based upon ionizing radiation or chemotherapeutic treatment may affect
breaking of DNA double strand in cell. DNA-PK enzyme has emerged as an attractive target …
breaking of DNA double strand in cell. DNA-PK enzyme has emerged as an attractive target …
Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8-and 6-aryl-substituted-1-3-benzoxazines
R Morrison, JMA Al-Rawi, IG Jennings… - European journal of …, 2016 - Elsevier
Abstract The synthesis of 6-aryl, 8-aryl, and 8-aryl-6-chloro-2-morpholino-1, 3-benzoxazines
with potent activity against PI3K and DNA-PK is described. Synthesis of thirty one analogues …
with potent activity against PI3K and DNA-PK is described. Synthesis of thirty one analogues …
Bio‐based benzoxazines synthesized in a deep eutectic solvent: A greener approach toward vesicular nanosystems
A green synthesis of benzoxazines, based upon reaction of cardanol with formaldehyde and
primary amines, is achieved in high yields using choline chloride‐urea mixture as deep …
primary amines, is achieved in high yields using choline chloride‐urea mixture as deep …
1, 3‐Oxazine as a promising scaffold for the development of biologically active lead molecules
Heterocyclic compounds form an important part of wide range of biologically active
molecules. The heteroatom provides them specificity for various receptors. 1, 3‐oxazine has …
molecules. The heteroatom provides them specificity for various receptors. 1, 3‐oxazine has …