Mammalian prion diseases are a group of neurodegenerative conditions caused by infection
of the central nervous system with proteinaceous agents called prions, including sporadic …

In the past, natural scrapie and bovine spongiform encephalopathy (BSE) infections have
essentially not been diagnosed in sheep homozygous for the A 136 R 154 R 171 haplotype …

Isolates of atypical scrapie recently identified in sheep and goats in France were compared
with Nor98 isolates reported in Norway. Western blot methods for characterization of the …

Since 1987, when bovine spongiform encephalopathy (BSE) emerged as a novel disease in
cattle, enormous efforts were undertaken to monitor and control the disease in ruminants …

In goats, several field studies have identified coding mutations of the gene encoding the
prion protein (I/M142, N/D146, S/D146, R/Q211, and Q/K222) that are associated with a …

The presence of BSE prion infectivity in asymptomatic cattle and its tissue distribution are
important concerns for both human and veterinary health and food safety. In this work, a …

Featuring contributions from specialists in related research areas, this book presents expert
summaries on state-of-the-art diagnostic approaches for major animal viral pathogens, with …

How susceptible pigs are to infection with sheep prions is unknown. We show, through
transmission experiments in transgenic mice expressing porcine prion protein (PrP), that the …

The host encoded cellular prion protein (PrPC) is an N-linked glycoprotein tethered to the
cell membrane by a glycophosphatidylinositol (GPI) anchor. Under certain conditions, PrPC …

Sheep are natural hosts of the prion disease, scrapie. They are also susceptible to
experimental challenge with various scrapie strains and with bovine spongiform …