Genetic factors in mammalian prion diseases
S Mead, S Lloyd, J Collinge - Annual review of genetics, 2019 - annualreviews.org
Mammalian prion diseases are a group of neurodegenerative conditions caused by infection
of the central nervous system with proteinaceous agents called prions, including sporadic …
of the central nervous system with proteinaceous agents called prions, including sporadic …
[HTML][HTML] Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France
MH Groschup, C Lacroux, A Buschmann… - Emerging infectious …, 2007 - ncbi.nlm.nih.gov
In the past, natural scrapie and bovine spongiform encephalopathy (BSE) infections have
essentially not been diagnosed in sheep homozygous for the A 136 R 154 R 171 haplotype …
essentially not been diagnosed in sheep homozygous for the A 136 R 154 R 171 haplotype …
[HTML][HTML] Similar biochemical signatures and prion protein genotypes in atypical scrapie and Nor98 cases, France and Norway
JN Arsac, O Andreoletti, JM Bilheude… - Emerging infectious …, 2007 - ncbi.nlm.nih.gov
Isolates of atypical scrapie recently identified in sheep and goats in France were compared
with Nor98 isolates reported in Norway. Western blot methods for characterization of the …
with Nor98 isolates reported in Norway. Western blot methods for characterization of the …
Atypical transmissible spongiform encephalopathies in ruminants: a challenge for disease surveillance and control
T Seuberlich, D Heim… - Journal of veterinary …, 2010 - journals.sagepub.com
Since 1987, when bovine spongiform encephalopathy (BSE) emerged as a novel disease in
cattle, enormous efforts were undertaken to monitor and control the disease in ruminants …
cattle, enormous efforts were undertaken to monitor and control the disease in ruminants …
Genetic resistance to scrapie infection in experimentally challenged goats
C Lacroux, C Perrin-Chauvineau, F Corbière… - Journal of …, 2014 - Am Soc Microbiol
In goats, several field studies have identified coding mutations of the gene encoding the
prion protein (I/M142, N/D146, S/D146, R/Q211, and Q/K222) that are associated with a …
prion protein (I/M142, N/D146, S/D146, R/Q211, and Q/K222) that are associated with a …
Progression of prion infectivity in asymptomatic cattle after oral bovine spongiform encephalopathy challenge
The presence of BSE prion infectivity in asymptomatic cattle and its tissue distribution are
important concerns for both human and veterinary health and food safety. In this work, a …
important concerns for both human and veterinary health and food safety. In this work, a …
[图书][B] Molecular detection of animal viral pathogens
D Liu - 2016 - books.google.com
Featuring contributions from specialists in related research areas, this book presents expert
summaries on state-of-the-art diagnostic approaches for major animal viral pathogens, with …
summaries on state-of-the-art diagnostic approaches for major animal viral pathogens, with …
[HTML][HTML] Transgenic mice expressing porcine prion protein resistant to classical scrapie but susceptible to sheep bovine spongiform encephalopathy and atypical …
JC Espinosa, ME Herva, O Andréoletti… - Emerging Infectious …, 2009 - ncbi.nlm.nih.gov
How susceptible pigs are to infection with sheep prions is unknown. We show, through
transmission experiments in transgenic mice expressing porcine prion protein (PrP), that the …
transmission experiments in transgenic mice expressing porcine prion protein (PrP), that the …
Quantitative and qualitative analysis of cellular prion protein (PrPC) expression in bovine somatic tissues
OA Peralta, WH Eyestone - Prion, 2009 - Taylor & Francis
The host encoded cellular prion protein (PrPC) is an N-linked glycoprotein tethered to the
cell membrane by a glycophosphatidylinositol (GPI) anchor. Under certain conditions, PrPC …
cell membrane by a glycophosphatidylinositol (GPI) anchor. Under certain conditions, PrPC …
Comparative Susceptibility of Sheep of Different Origins, Breeds and PRNP Genotypes to Challenge with Bovine Spongiform Encephalopathy and Scrapie
F Houston, W Goldmann, J Foster, L González… - PloS one, 2015 - journals.plos.org
Sheep are natural hosts of the prion disease, scrapie. They are also susceptible to
experimental challenge with various scrapie strains and with bovine spongiform …
experimental challenge with various scrapie strains and with bovine spongiform …