Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

One of the most fascinating and unusual features of trypanosomatids, parasites that cause
disease in many tropical countries, is their mitochondrial DNA. This genome, known as …

Mitochondrial DNA replication is an essential process in most eukaryotes. Similar to the
diversity in mitochondrial genome size and organization in the different eukaryotic …

The tripartite attachment complex (TAC) of the single mitochondrion of trypanosomes allows
precise segregation of its single nucleoid mitochondrial genome during cytokinesis. It …

The defined shape and single-copy organelles of Trypanosoma brucei mean that it provides
an excellent model in which to study how duplication and segregation of organelles is …

Background Trypanosoma brucei undergoes genetic exchange in its insect vector, the tsetse
fly, by an unknown mechanism. The difficulties of working with this experimental system of …

Unlike most other model eukaryotes, Trypanosoma brucei and its relatives have a single
mitochondrion with a single-unit mitochondrial genome that is termed kinetoplast DNA …

The mitochondrial DNA of Trypanosoma brucei is organized in a complex structure called
the kinetoplast. In this study, we define the complete kinetoplast duplication cycle in T. brucei …

The mitochondrial genome of kinetoplastids, called kinetoplast DNA (kDNA) is a complex
structure that must be faithfully duplicated exactly once per cell cycle. Despite many years of …

In almost all eukaryotes, mitochondria maintain their own genome. Despite the discovery
more than 50 y ago, still very little is known about how the genome is correctly segregated …