Preventing type 1 diabetes in childhood

CM Dayan, REJ Besser, RA Oram, W Hagopian… - Science, 2021 - science.org
Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells of
the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that …

Autoimmune diseases: targets, biology, and drug discovery

S Li, Y Wu, J Chen, S Shen, J Duan… - Acta Pharmacologica …, 2024 - nature.com
Autoimmune diseases (AIDs) arise from a breakdown in immunological self-tolerance,
wherein the adaptive immune system mistakenly attacks healthy cells, tissues and organs …

Effectiveness of the freestyle libre 2 flash glucose monitoring system on diabetes-self-management practices and glycemic parameters among patients with type 1 …

AA Al Hayek, AA Robert, MA Al Dawish - Diabetes & Metabolic Syndrome …, 2021 - Elsevier
Aims To determine the effectiveness of Freestyle Libre 2 (FSL2) on diabetes-self-
management (DSM) practices and glycemic parameters among patients with type 1 diabetes …

[HTML][HTML] Parallel multi-omics in high-risk subjects for the identification of integrated biomarker signatures of type 1 diabetes

O Alcazar, LF Hernandez, ES Nakayasu, CD Nicora… - Biomolecules, 2021 - mdpi.com
Background: Biomarkers are crucial for detecting early type-1 diabetes (T1D) and preventing
significant β-cell loss before the onset of clinical symptoms. Here, we present proof-of …

Mechanism-driven strategies for prevention of rheumatoid arthritis

VM Holers, KA Kuhn, MK Demoruelle… - Rheumatology & …, 2022 - mednexus.org
In seropositive rheumatoid arthritis (RA), the onset of clinically apparent inflammatory
arthritis (IA) is typically preceded by a prolonged period of autoimmunity manifest by the …

Prediabetes in adolescents: prevalence, management and diabetes prevention strategies

R Esquivel Zuniga, MD DeBoer - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
The ongoing obesity epidemic in children and adolescents has greatly increased the
prevalence of related comorbidities. Prediabetes is defined based on levels of fasting …

[HTML][HTML] Modeling type 1 diabetes using pluripotent stem cell technology

K Joshi, F Cameron, S Tiwari, SI Mannering… - Frontiers in …, 2021 - frontiersin.org
Induced pluripotent stem cell (iPSC) technology is increasingly being used to create in vitro
models of monogenic human disorders. This is possible because, by and large, the …

Predicting Immunological risk for stage 1 and stage 2 diabetes using a 1-week CGM home test, nocturnal glucose increments, and standardized liquid mixed meal …

E Montaser, MD Breton, SA Brown… - Diabetes Technology …, 2023 - liebertpub.com
Background: Predicting the risk for type 1 diabetes (T1D) is a significant challenge. We use a
1-week continuous glucose monitoring (CGM) home test to characterize differences in …

[HTML][HTML] Population-based estimates of humoral autoimmunity from the US National Health and Nutrition Examination Surveys, 1960–2014

CF Dillon, MH Weisman, FW Miller - PLoS One, 2020 - journals.plos.org
Objective Based on US National Health and Nutrition Examination Survey (NHANES) data,
we attempted to provide an unbiased, population-based estimate of autoantibody …

Persistence of β-cell responsiveness for over two years in autoantibody-positive children with marked metabolic impairment at screening

EK Sims, D Cuthbertson, JL Felton, HM Ismail… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE We studied longitudinal differences between progressors and nonprogressors
to type 1 diabetes with similar and substantial baseline risk. RESEARCH DESIGN AND …