Preventing type 1 diabetes in childhood
Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells of
the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that …
the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that …
Autoimmune diseases: targets, biology, and drug discovery
S Li, Y Wu, J Chen, S Shen, J Duan… - Acta Pharmacologica …, 2024 - nature.com
Autoimmune diseases (AIDs) arise from a breakdown in immunological self-tolerance,
wherein the adaptive immune system mistakenly attacks healthy cells, tissues and organs …
wherein the adaptive immune system mistakenly attacks healthy cells, tissues and organs …
Effectiveness of the freestyle libre 2 flash glucose monitoring system on diabetes-self-management practices and glycemic parameters among patients with type 1 …
AA Al Hayek, AA Robert, MA Al Dawish - Diabetes & Metabolic Syndrome …, 2021 - Elsevier
Aims To determine the effectiveness of Freestyle Libre 2 (FSL2) on diabetes-self-
management (DSM) practices and glycemic parameters among patients with type 1 diabetes …
management (DSM) practices and glycemic parameters among patients with type 1 diabetes …
[HTML][HTML] Parallel multi-omics in high-risk subjects for the identification of integrated biomarker signatures of type 1 diabetes
Background: Biomarkers are crucial for detecting early type-1 diabetes (T1D) and preventing
significant β-cell loss before the onset of clinical symptoms. Here, we present proof-of …
significant β-cell loss before the onset of clinical symptoms. Here, we present proof-of …
Mechanism-driven strategies for prevention of rheumatoid arthritis
VM Holers, KA Kuhn, MK Demoruelle… - Rheumatology & …, 2022 - mednexus.org
In seropositive rheumatoid arthritis (RA), the onset of clinically apparent inflammatory
arthritis (IA) is typically preceded by a prolonged period of autoimmunity manifest by the …
arthritis (IA) is typically preceded by a prolonged period of autoimmunity manifest by the …
Prediabetes in adolescents: prevalence, management and diabetes prevention strategies
R Esquivel Zuniga, MD DeBoer - Diabetes, Metabolic Syndrome …, 2021 - Taylor & Francis
The ongoing obesity epidemic in children and adolescents has greatly increased the
prevalence of related comorbidities. Prediabetes is defined based on levels of fasting …
prevalence of related comorbidities. Prediabetes is defined based on levels of fasting …
[HTML][HTML] Modeling type 1 diabetes using pluripotent stem cell technology
Induced pluripotent stem cell (iPSC) technology is increasingly being used to create in vitro
models of monogenic human disorders. This is possible because, by and large, the …
models of monogenic human disorders. This is possible because, by and large, the …
Predicting Immunological risk for stage 1 and stage 2 diabetes using a 1-week CGM home test, nocturnal glucose increments, and standardized liquid mixed meal …
E Montaser, MD Breton, SA Brown… - Diabetes Technology …, 2023 - liebertpub.com
Background: Predicting the risk for type 1 diabetes (T1D) is a significant challenge. We use a
1-week continuous glucose monitoring (CGM) home test to characterize differences in …
1-week continuous glucose monitoring (CGM) home test to characterize differences in …
[HTML][HTML] Population-based estimates of humoral autoimmunity from the US National Health and Nutrition Examination Surveys, 1960–2014
CF Dillon, MH Weisman, FW Miller - PLoS One, 2020 - journals.plos.org
Objective Based on US National Health and Nutrition Examination Survey (NHANES) data,
we attempted to provide an unbiased, population-based estimate of autoantibody …
we attempted to provide an unbiased, population-based estimate of autoantibody …
Persistence of β-cell responsiveness for over two years in autoantibody-positive children with marked metabolic impairment at screening
OBJECTIVE We studied longitudinal differences between progressors and nonprogressors
to type 1 diabetes with similar and substantial baseline risk. RESEARCH DESIGN AND …
to type 1 diabetes with similar and substantial baseline risk. RESEARCH DESIGN AND …