The effect of HIF on metabolism and immunity

CT Taylor, CC Scholz - Nature Reviews Nephrology, 2022 - nature.com
Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

Noncoding RNA therapeutics—challenges and potential solutions

M Winkle, SM El-Daly, M Fabbri, GA Calin - Nature reviews Drug …, 2021 - nature.com
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …

The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment

A Emami Nejad, S Najafgholian, A Rostami… - Cancer Cell …, 2021 - Springer
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …

FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair

P Mathiyalagan, M Adamiak, J Mayourian, Y Sassi… - Circulation, 2019 - Am Heart Assoc
Background: Despite its functional importance in various fundamental bioprocesses, studies
of N6-methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass …

MicroRNAs and complex diseases: from experimental results to computational models

X Chen, D Xie, Q Zhao, ZH You - Briefings in bioinformatics, 2019 - academic.oup.com
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

YL Hsu, JY Hung, WA Chang, YS Lin, YC Pan, PH Tsai… - Oncogene, 2017 - nature.com
Hypoxia plays a critical role during the evolution of malignant cells and tumour
microenvironment (TME). Tumour-derived exosomes contain informative microRNAs …

miRNA deregulation in cancer cells and the tumor microenvironment

R Rupaimoole, GA Calin, G Lopez-Berestein, AK Sood - Cancer discovery, 2016 - AACR
Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …

Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype

L Li, C Li, S Wang, Z Wang, J Jiang, W Wang, X Li… - Cancer research, 2016 - AACR
Hypoxia is a common feature of solid tumors and is associated with aggressiveness and
poor patient outcomes. Exosomes, initially considered to be cellular “garbage dumpsters,” …

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia

L Zheng, CJ Kelly, SP Colgan - American Journal of …, 2015 - journals.physiology.org
In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …