The effect of HIF on metabolism and immunity
Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …
produce the levels of ATP required to perform physiological functions exceeds the vascular …
Noncoding RNA therapeutics—challenges and potential solutions
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment
A Emami Nejad, S Najafgholian, A Rostami… - Cancer Cell …, 2021 - Springer
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
R Rupaimoole, FJ Slack - Nature reviews Drug discovery, 2017 - nature.com
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair
Background: Despite its functional importance in various fundamental bioprocesses, studies
of N6-methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass …
of N6-methyladenosine (m6A) in the heart are lacking. Here, we show that the FTO (fat mass …
MicroRNAs and complex diseases: from experimental results to computational models
Plenty of microRNAs (miRNAs) were discovered at a rapid pace in plants, green algae,
viruses and animals. As one of the most important components in the cell, miRNAs play a …
viruses and animals. As one of the most important components in the cell, miRNAs play a …
Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1
YL Hsu, JY Hung, WA Chang, YS Lin, YC Pan, PH Tsai… - Oncogene, 2017 - nature.com
Hypoxia plays a critical role during the evolution of malignant cells and tumour
microenvironment (TME). Tumour-derived exosomes contain informative microRNAs …
microenvironment (TME). Tumour-derived exosomes contain informative microRNAs …
miRNA deregulation in cancer cells and the tumor microenvironment
R Rupaimoole, GA Calin, G Lopez-Berestein, AK Sood - Cancer discovery, 2016 - AACR
Abstract miRNAs are a key component of the noncoding RNA family. The underlying
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …
mechanisms involved in the interplay between the tumor microenvironment and cancer cells …
Exosomes derived from hypoxic oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a prometastatic phenotype
L Li, C Li, S Wang, Z Wang, J Jiang, W Wang, X Li… - Cancer research, 2016 - AACR
Hypoxia is a common feature of solid tumors and is associated with aggressiveness and
poor patient outcomes. Exosomes, initially considered to be cellular “garbage dumpsters,” …
poor patient outcomes. Exosomes, initially considered to be cellular “garbage dumpsters,” …
Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A review in the theme: cellular responses to hypoxia
In recent years, the intestinal mucosa has proven to be an intriguing organ to study tissue
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …
oxygenation. The highly vascularized lamina propria juxtaposed to an anaerobic lumen …